Indian Journal of Pathology and Microbiology
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Year : 2016  |  Volume : 59  |  Issue : 3  |  Page : 395-397

Unusual ganglioglioma with extensive calcification and ossification

Department of Histopathology, Metropolis Healthcare Limited, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Vikas Shashikant Kavishwar
Department of Histopathology, Metropolis Healthcare Limited, Central Laboratory, 4th Floor, Commercial Building - 1A, Kohinoor Mall, Vidyavihar (West), Mumbai - 400 070, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.188115

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Ganglioglioma is a slow-growing relatively low-grade mixed glioneuronal tumor with most cases corresponding to the WHO Grade I category. It frequently presents with seizures. The temporal lobe is the most common location followed by frontal, parietal, and occipital lobes. These generally behave in a benign fashion and have a favorable prognosis. We describe a case of a 24-year-old male presenting with convulsions and a calcified parieto-occipital mass. This mass removed from the parietal lobe showed neoplastic glial and dysplastic neuronal tissue amidst extensive areas of calcification and foci of ossification. On immunohistochemistry, the glial component expressed glial fibrillary acidic protein whereas the dysplastic neuronal component expressed synaptophysin and CD34. Epithelial membrane antigen was negative and Ki-67 showed a low proliferative index. After the surgery, the patient is free of neurological symptoms. Widespread calcification and ossification are very unusual in ganglioglioma, which prompted us to report this case.

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