LGCmain
Indian Journal of Pathology and Microbiology
Home About us Instructions Submission Subscribe Advertise Contact e-Alerts Ahead Of Print Login 
Users Online: 1107
Print this page  Email this page Bookmark this page Small font sizeDefault font sizeIncrease font size
ORIGINAL ARTICLE
Year : 2017  |  Volume : 60  |  Issue : 3  |  Page : 324-327

Correlation between human epidermal growth factor receptor 2 oncoprotein expression and some prognostic factors in papillary thyroid carcinoma


1 Medical Students Research Committee, Shahed University, Tehran, Iran
2 Department of Pathology and Anatomy, College of Medicine, Shahed University, Tehran, Iran

Correspondence Address:
Shervin Rabiee
No. 44, Gisha Street, Tehran
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJPM.IJPM_332_15

Rights and Permissions

Background: Thyroid cancer is one of the increasing cancer diagnoses in the United States. Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. There are a few researches done determining the role of human epidermal growth factor receptor 2 HER2 (erbB-2) in PTC prognosis. They also have been controversial. This study is designed to determine the correlation of HER2 expression with tumor size, lymph node involvement, and capsular invasion as prognostic factors. Materials and Methods: This research was a cross-sectional descriptive-analytic study. Information about age, sex, tumor size, and lymph node involvement of 85 patients undergone thyroidectomy and diagnosed PTC in Mostafa Khomeini Hospital during 2010–2012, have been derived from their medical records. Four-micron sections made from paraffin embedded blocks and HER2 expression was assessed by immunohistochemistry. Other sections were stained with H and E Method and capsular invasion was evaluated by microscope. Results: In this study, 88.2% of patients were female and 11.8% of patients were male. About 37.6% of samples were HER2 positive. There was no significant correlation between HER2 and lymph node involvement (P = 0.649), (P > 0.05). A significant correlation found between HER2 and capsular invasion (P = 0.000), (P < 0.05). This study found a significant correlation between HER2 and tumor size (P = 0.000), (P < 0.05). Conclusion: HER2 oncoprotein expression is correlated with increased tumor size and capsular invasion. Hence, HER2 can be used to assess PTC prognosis.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2821    
    Printed43    
    Emailed0    
    PDF Downloaded231    
    Comments [Add]    

Recommend this journal