Indian Journal of Pathology and Microbiology
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Year : 2017  |  Volume : 60  |  Issue : 3  |  Page : 409-411

Nonspecific granulomatous prostatitis in association with eosinophilic epithelial metaplasia and prostatic adenocarcinoma

1 Department of Pathology, Jossigny Hospital, Jossigny, France
2 Department of General and Clinical Pathology, Medical University - Plovdiv, Plovdiv, Bulgaria

Correspondence Address:
Maria Stoyanova Koleva
Department of General and Clinical Pathology, Medical University - Plovdiv, Bul., Vasil Aprilov 15A, Plovdiv
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPM.IJPM_130_16

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We present the first case of nonspecific granulomatous prostatitis (NSGP) associated with both eosinophilic epithelial metaplasia (EM) in benign glands and prostatic adenocarcinoma (PCa). The patient was a 68-year old man with a history of obstructive prostatic syndrome. After a transurethral resection of the prostate, the histologic analysis revealed NSGP and PCa. EM was seen in benign peri-granulomatous secretory epithelial cells as PAS Diastase positive granular eosinophilic transformation of the apical cell cytoplasm. This unusual cell appearance closely simulated the Paneth cell-like changes found in PCa. Negative chromogranin expression and weakly positive P504S immune staining in the foci of EM, surrounded by P63 positive basal cells confirmed the benign EM - phenotype. The combination of NSGP with both EM and PCa has not been reported in medical literature so far. Some observations concerning their differential diagnosis are suggested.

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