Applicability of 2008 World Health Organization classification system of hematolymphoid neoplasms: Learning experiences

Sushil Modkharkar; Pooja Navale; Pratibha Kadam Amare; Anuradha Chougule; Nikhil Patkar; Prashant Tembhare; Hari Menon; Manju Sengar; Navin Khattry; Shripad Banavali; Brijesh Arora; Gaurav Narula; Siddhartha Laskar; Nehal Khanna; Mary Ann Muckaden; Venkatesh Rangarajan; Archi Agrawal; Tanuja Shet; Sridhar Epari; PG Subramanian; Sumeet Gujral

doi:10.4103/IJPM.IJPM_56_17

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ORIGINAL ARTICLE

Year : 2018 | Volume : 61 | Issue : 1 | Page : 58-65

Applicability of 2008 World Health Organization classification system of hematolymphoid neoplasms: Learning experiences

Sushil Modkharkar¹, Pooja Navale¹, Pratibha Kadam Amare², Anuradha Chougule³, Nikhil Patkar³, Prashant Tembhare³, Hari Menon⁴, Manju Sengar⁴, Navin Khattry⁴, Shripad Banavali⁴, Brijesh Arora⁴, Gaurav Narula⁴, Siddhartha Laskar⁵, Nehal Khanna⁵, Mary Ann Muckaden⁶, Venkatesh Rangarajan⁷, Archi Agrawal⁷, Tanuja Shet¹, Sridhar Epari¹, PG Subramanian³, Sumeet Gujral⁸
¹ Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India
² Department of Cancer Cytogenetics, Tata Memorial Hospital, Mumbai, Maharashtra, India
³ Department of Pathology, Hematopathology Laboratory, Tata Memorial Hospital, Mumbai, Maharashtra, India
⁴ Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
⁵ Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
⁶ Department of Palliative Medicine, Tata Memorial Hospital, Mumbai, Maharashtra, India
⁷ Department of Radiology and Nuclear Medicine, Tata Memorial Hospital, Mumbai, Maharashtra, India
⁸ Department of Pathology, Tata Memorial Hospital; Department of Pathology, Hematopathology Laboratory, Tata Memorial Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Sumeet Gujral
Hematopathology Laboratory, 727, 7^th Floor, Annexe Building, Tata Memorial Hospital, Dr. Ernest Borges Road, Parel, Mumbai - 400 012, Maharashtra
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/IJPM.IJPM_56_17

Background: 2008 World Health Organization (WHO) classification of hematolymphoid neoplasms (HLN) has classified them based on morphology, results of various ancillary techniques, and clinical features.^[1] There are no studies looking at the applicability of WHO classification. Aims: The aim of the study was to calculate proportions of all HLN subtypes seen during 1-year period based on 2008 WHO classification of HLN and study applicability and also shortcomings of practices in a tertiary care center in India. Materials and Methods: This was a 1-year retrospective study (January 1^st, to December 31^st, 2010) where cases were identified using hospital/laboratory electronic records. Old follow-up and referral cases were excluded from the study. Only newly diagnosed cases classified into categories laid down by 2008 WHO classification of HLN included. Results: Out of 2118 newly diagnosed classifiable cases, 1602 (75.6%) cases were of lymphoid neoplasms, 489 (23.1%) cases of myeloid neoplasms, 16 (0.8%) cases of histiocytic and dendritic cell neoplasms, and 11 (0.5%) cases of acute leukemias of ambiguous lineage. Overall, most common HLN subtype was diffuse large B-cell lymphoma (n = 361, 17.0%). Precursor B-lymphoblastic leukaemia/lymphoma (n = 177, 48.2%) was the most common subtype within pediatric age group. Conclusions: All major subtypes of HLN were seen at our center and showed trends almost similar to those seen in other Indian studies. Molecular/cytogenetic studies could not be performed on a significant number of cases owing to logistic reasons (unavailability of complete panels and also cost-related issues) and such cases could not be classified as per the WHO classification system.

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