Indian Journal of Pathology and Microbiology
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Year : 2018  |  Volume : 61  |  Issue : 2  |  Page : 225-227

Expression of E-cadherin, syndecan 1, Ki-67, and maintenance minichromosome 3 in tissue lesions of actinic prurigo obtained by incisional biopsy

1 Department of Dermatology, “Dr. Manuel Gea González” General Hospital, Mexico City, Mexico
2 Faculty of Dentistry, University of the Republic, Montevideo, Uruguay
3 Department of Stomatology, Institute of Biomedical Sciences, Autonomous University of Ciudad Juarez, Chihuahua, Mexico

Correspondence Address:
María Elisa Vega-Memije
Department of Dermatology, “Dr. Manuel Gea González” General Hospital, Calzada De Tlalpan 4800, Sección XVI, Delegación Tlalpan México, D.F. C.P 14080
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPM.IJPM_574_17

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Actinic prurigo (AP) is an idiopathic photodermatosis; the initial manifestations usually occur during the first decades of life but can appear at any age. Cases are usually diagnosed late once the lesions have exacerbated; due to the extensive involvement of the vermilion border and the etiology, it has been confused with and related to a potentially malignant process. Syndecan-1 and E-cadherin were positive in the epidermis, with moderate-to-intense staining in 100% of samples. Ki67 and MCM3 were expressed in the lower third of the epidermis and showed greater immunolabeling in samples that contained lymphoid follicles (Ki 67: epidermis [17.7% ± 6.79%] and dermis [7.73% ± 6.69%]; MCM3: epidermis [22.92% ± 10.12%] and dermis [6.13% ± 6.27%]). In conclusión AP is a disease in which there is no evidence that the lesions are potentially cancerous. AP cheilitis should not be confused with actinic cheilitis because they are separate entities.

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