Indian Journal of Pathology and Microbiology
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Year : 2018  |  Volume : 61  |  Issue : 3  |  Page : 401-403

Duodenal neuroendocrine tumor, adenocarcinoma and gastrointestinal stromal tumor in association with neurofibromatosis type 1: An unique occurrence

Department of Pathology, Sagar Hospital, Bengaluru, Karnataka, India

Correspondence Address:
P Somasekhara Reddy
Department of Laboratory Medicine, Sagar Hospital, Tilak Nagar, Jayanagar Extension, Bengaluru - 560 041, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPM.IJPM_534_17

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Mixed endocrine–nonendocrine neoplasms are rare tumors and pose challenges in diagnosis and management. Neurofibromatosis-1 (NF-1) patients are known to develop malignancies. Although neuroendocrine tumors and gastro-intestinal stromal tumors are seen in NF-1, its association with adenocarcinoma is rare. The existence of these three entities with NF-1 is extremely rare. NF1 patients presenting with symptoms suggestive of malignancies should alert the physician for a detailed clinical work up. Diagnosis of these malignancies often requires a meticulous histopathological and immunohistochemical examination. We report the first case from Indian experience.

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