Indian Journal of Pathology and Microbiology
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Year : 2018  |  Volume : 61  |  Issue : 3  |  Page : 407-409

Sclerosing pneumocytoma with metastasis to the mediastinal and regional lymph nodes

1 Department of Geratology, First Affiliated Hospital, Dalian Medical University, Dalian, China
2 Department of Pathology, First Affiliated Hospital, Dalian Medical University, Dalian, China

Correspondence Address:
Hua Zhang
Department of Geratology, First Affiliated Hospital, Dalian Medical University, 222 Zhongshan Road, Xigang District, Dalian 116011, Liaoning Province
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPM.IJPM_98_17

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Sclerosing pneumocytoma (SP) is an uncommon benign tumor, and metastasis of SP has been rarely reported. Here, we report the case of a 26-year-old woman with surgically confirmed SP. The tumor diameter was 40 mm, and metastasis to mediastinal and regional lymph nodes was observed. Immunohistochemically, both surface and round cells were positive for epithelial membrane antigen, thyroid transcription factor 1, and vimentin. Only surface cells expressed creatine kinase, carcinoembryonic antigen, napsin A, and cytokeratin 7, and only round cells expressed progesterone receptor. Ki-67 was detected in ~3% of cells, and the rate of weak positive p53 staining was 3%. Both cell types were negative for chromogranin A, synaptophysin, CD3, and CK20. Multiple metastases in a young SP patient are very rare, and potential mechanisms of metastasis may be related to epithelial–mesenchymal transformation.

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