LGCmain
Indian Journal of Pathology and Microbiology
Home About us Instructions Submission Subscribe Advertise Contact e-Alerts Ahead Of Print Login 
Users Online: 436
Print this page  Email this page Bookmark this page Small font sizeDefault font sizeIncrease font size
CASE REPORT
Year : 2018  |  Volume : 61  |  Issue : 3  |  Page : 407-409

Sclerosing pneumocytoma with metastasis to the mediastinal and regional lymph nodes


1 Department of Geratology, First Affiliated Hospital, Dalian Medical University, Dalian, China
2 Department of Pathology, First Affiliated Hospital, Dalian Medical University, Dalian, China

Correspondence Address:
Hua Zhang
Department of Geratology, First Affiliated Hospital, Dalian Medical University, 222 Zhongshan Road, Xigang District, Dalian 116011, Liaoning Province
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJPM.IJPM_98_17

Rights and Permissions

Sclerosing pneumocytoma (SP) is an uncommon benign tumor, and metastasis of SP has been rarely reported. Here, we report the case of a 26-year-old woman with surgically confirmed SP. The tumor diameter was 40 mm, and metastasis to mediastinal and regional lymph nodes was observed. Immunohistochemically, both surface and round cells were positive for epithelial membrane antigen, thyroid transcription factor 1, and vimentin. Only surface cells expressed creatine kinase, carcinoembryonic antigen, napsin A, and cytokeratin 7, and only round cells expressed progesterone receptor. Ki-67 was detected in ~3% of cells, and the rate of weak positive p53 staining was 3%. Both cell types were negative for chromogranin A, synaptophysin, CD3, and CK20. Multiple metastases in a young SP patient are very rare, and potential mechanisms of metastasis may be related to epithelial–mesenchymal transformation.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2468    
    Printed45    
    Emailed0    
    PDF Downloaded60    
    Comments [Add]    
    Cited by others 1    

Recommend this journal