Indian Journal of Pathology and Microbiology
Home About us Instructions Submission Subscribe Advertise Contact e-Alerts Ahead Of Print Login 
Users Online: 6209
Print this page  Email this page Bookmark this page Small font sizeDefault font sizeIncrease font size

  Table of Contents    
Year : 2019  |  Volume : 62  |  Issue : 2  |  Page : 345-346
Glandular odontogenic cyst: An unusual entity

1 Department of Oral Pathology and Microbiology, Manav Rachna Dental College, Faridabad, Haryana, India
2 Department of Periodontology, Manav Rachna Dental College, Faridabad, Haryana, India

Click here for correspondence address and email

Date of Web Publication10-Apr-2019

How to cite this article:
Sharma J, Raina AB, Varshney A, Chopra D. Glandular odontogenic cyst: An unusual entity. Indian J Pathol Microbiol 2019;62:345-6

How to cite this URL:
Sharma J, Raina AB, Varshney A, Chopra D. Glandular odontogenic cyst: An unusual entity. Indian J Pathol Microbiol [serial online] 2019 [cited 2022 Aug 12];62:345-6. Available from: https://www.ijpmonline.org/text.asp?2019/62/2/345/255832

Dear Editor,

Glandular odontogenic cyst (GOC) was first documented as “sialo-odontogenic cyst” by Padayachee and Van Wyk in 1987.[1] They published two cases that bear a resemblance to both the botryoid odontogenic cyst (BOC) and the central mucoepidermoid tumor of jaws. After careful analysis, they concluded both lesions as separate entities.[2] GOC is very rare, and only 111 cases have been documented in the English literature so far.[3] In general, this cyst is encountered in the anterior areas of the mandible, is more common with a wide age range, the mean age being 49.5 years, and has a tendency to recur. Radiographically, it is radiolucent, well-defied, either unilocular (53.8%), or multilocular (46.2%) with frequent perforation (61%) and thinning of cortical plates (24.4%).[4] Furthermore, English literature revealed recurrence rate that varies from 21%–55%, which indicates its aggressiveness.[2] Therefore, a confirmatory diagnosis is critical for treatment and follow-up.

A 43-year-old female patient reported with chief complaint of painful swelling in upper right front tooth region since 7–8 months. Extraorally, the swelling was not obvious and did not produce any facial asymmetry. Intraoral examination revealed a single palatal swelling in the right maxillary region extending from 11 to 13 (FDI tooth numbering system) approximately 3 × 1 cm in size. The overlying mucosa was of normal color and appearance [Figure 1]a. On palpation, the swelling was firm, non-tender, non-mobile, and non-pulsatile. A provisional diagnosis of ameloblastoma and differential diagnosis of odontogenic keratocyst was given.
Figure 1: (a) Swelling on the upper right anterior aspect (b) Unilocular radiolucency extending from 11 to 13 (c) Tissue section shows focal thickened plaques projecting into lumen (H and E, ×4) (d) Tissue section shows mucous cells (H and E, ×40)

Click here to view

The radiographic examination revealed a unilocular radiolucent area with well-defined sclerotic border extending from 11 to 13 regions along with root divergence [Figure 1]b. An incisional biopsy was done, and the specimen was sent for histopathological examination. The macroscopic examination revealed single tissue bit of 0.8 × 0.4 cm in size, creamish white in color, and firm in consistency.

The Hematoxylin and Eosin stained tissue section revealed thin non-keratinized stratified squamous epithelium showing focal thickened plaques projecting into lumen. The epithelium also shows mucous cells and some ciliated cells [Figure 1]c and [Figure 1]d. The underlying connective tissue stroma was fibrocellular with infiltration of chronic inflammatory cells chiefly lymphocytes and plasma cells. Blood vessels of varying size and shape were also evident. The histopathological features confirmed the diagnosis of GOC.

GOCs are rare intrabony solitary or multiloculated cysts of odontogenic origin. GOCs are now relatively well-known entities; their importance relates to the fact that they exhibit a propensity for recurrence rates from 21% to 55%, similar to odontogenic keratocysts and may be confused microscopically with central mucoepidermoid carcinoma (CMEC).[5] The GOC is included in the WHO histologic typing of odontogenic tumors under the terms GOC or sialo-odontogenic cyst.[6] To the best of our knowledge, only 111 cases of GOC has been reported in the literature, and Magnusson et al. observed that only 0.012% of the cysts seen on the oral cavity have fulfilled the criteria of GOC microscopically.[7] There is a slight male predilection, and lesions occur mostly in middle-aged patients. The main clinical finding in this cyst is a painless local swelling; the clinical picture, however, is non-specific.[2]

Histopathologically, GOC should be differentiated from lateral periodontal cyst (LPC) and CMEC as they exhibit considerable overlap of histological features. The lining of LPC exhibits focal thickenings and glycogen-rich epithelial cells, similar to those observed in GOC. However, the identification of ciliated epithelium and duct-like spaces with mucous cells specifically differentiate GOC from LPC and BOC and favors the diagnosis of GOC.[8] Treatment by enucleation or curettage alone is associated with a high recurrence rate. The surgical treatment of large lesions should include enucleation with peripheral ostectomy for unilocular cases and marginal resection or partial jaw resection in multilocular cases. Follow-up should be continued for at least 3 years.[2]

The purpose of this case is to increase the existing knowledge of this rare entity as histopathological diagnosis, and differential diagnosis of GOC is challenging for a pathologist.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

Azmi KE, Patel S, Pathak J, Swain N. Glandular odontogeniccyst mimicker: A novel entity. J Contemp Dent 2016;6:145-8.  Back to cited text no. 1
Shah M, Kale H, Ranginwala A, Patel G. Glandular odontogenic cyst: A rare entity. J Oral Maxillofac Pathol 2014;18:89-92.  Back to cited text no. 2
[PUBMED]  [Full text]  
Kaplan I, Anavi Y, Hirshberg A. Glandular odontogenic cyst: A challenge in diagnosis and treatment. Oral Dis 2008;14:575-81.  Back to cited text no. 3
Rajendran R, Sivapathasundharam B. Shafer's Textbook of Oral Pathology. 5th ed. Elsevier; 2006:77-9.  Back to cited text no. 4
Tambawala SS, Karjodkar FR, Yadav A, Sansare K, Sontakke S. Glandular odontogenic cyst: A case report. Imaging Sci Dent 2014;44:75-9.  Back to cited text no. 5
Kramer IRH, Pindborg JJ, Shear M. Histological Typing of Odontogenic Tumors. 2nd ed. Berlin: Springer; 1992.  Back to cited text no. 6
Krishnamurthy A, Sherlin HR, Ramalingam K, Natesan A, Premkumar P, Ramani P, et al. Glandular odontogeniccyst: Report of two cases and reviewof literature. Head Neck Pathol 2009;3:153-8.  Back to cited text no. 7
Prabhu S, Rekha K, Kumar GS. Glandular odontogenic cystmimicking central mucoepidermoid carcinoma. J Oral Maxillofac Pathol 2010;14:12-5.  Back to cited text no. 8
[PUBMED]  [Full text]  

Correspondence Address:
Jaishree Sharma
856, Dr. Mukherjee Nagar, Delhi - 110 009
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPM.IJPM_596_18

Rights and Permissions


  [Figure 1]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  

    Article Figures

 Article Access Statistics
    PDF Downloaded98    
    Comments [Add]    

Recommend this journal