Indian Journal of Pathology and Microbiology
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Year : 2020  |  Volume : 63  |  Issue : 2  |  Page : 251-254

Management of transfusion needs in a case of immunizing anti-M antibody in a patient with acute myeloid leukemia

Department of Transfusion Medicine, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India

Correspondence Address:
Priti Desai
Department of Transfusion Medicine, Tata Memorial Hospital, 5th Floor Service Block, Dr E Borges Road, Parel Mumbai - 400 012, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPM.IJPM_166_19

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Anti-M is a relatively common “naturally occurring” antibody. Unexpected alloantibodies in patient's serum other than ABO isoagglutinins (e.g., anti-M) may cause a discrepancy in the reverse grouping. As long as anti-M does not react at 37°C, it is clinically insignificant for transfusion. However, we found this antibody to be of “immunizing” type which was reactive at 37°C and AHG phase and showing problems in blood grouping and crossmatch. This antibody had both IgM and IgG components. When “M” antibodies active at 37°C are encountered, antigen-negative or red cells that are compatible with an indirect antiglobulin test should be provided.

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