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Indian Journal of Pathology and Microbiology
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ORIGINAL ARTICLE
Year : 2020  |  Volume : 63  |  Issue : 4  |  Page : 544-550

The clinical usefulness of chemokine C-X-C Motif Ligand 12 as a diagnostic marker for Papillary Thyroid Carcinoma


1 Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju City, Republic of Korea
2 Department of Surgery, Jeju National University Hospital, Jeju National University School of Medicine, Jeju City, Republic of Korea
3 Department of Anethesiology, Jeju National University Hospital, Jeju National University School of Medicine, Jeju City, Republic of Korea
4 Department of Thoracic and Cardiovascular Surgery, Jeju National University Hospital, Jeju National University School of Medicine, Jeju City, Republic of Korea
5 Department of Pathology Jeju National University Hospital, Jeju National University School of Medicine, Jeju City, Republic of Korea

Correspondence Address:
Young Hee Maeng
Aran 13 gil, Jeju.si, Jeju Special Self.Governing Province - 63241
Republic of Korea
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJPM.IJPM_722_19

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Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer worldwide. It is essential to develop methods for the accurate diagnosis of PTC to avoid unnecessary surgery. The chemokine C-X-C motif ligand 12 (CXCL12) is associated with various cancers. We aimed to investigate the efficacy of CXCL12 in the diagnosis of PTC in fine-needle aspiration (FNA) specimens. Methods: We prospectively collected samples from 58 patients who were scheduled for surgical treatment of PTC from 2013 to 2015. Tissue samples of 31 people with benign thyroid conditions were used as controls. Immunocytochemical and immunohistochemical staining for CXCL12 was performed on FNAs and corresponding tissue specimens. B-type Raf kinase (BRAF) V600E mutant protein expression and gene mutation were also analyzed to compare the clinical usefulness. Results: The mean age of the patients was 49.1 ± 1.4 years and 88.1% were women. Positive CXCL12 staining was observed in 6.5% of benign and in 98.3% of PTC samples; positive BRAF V600E mutant protein expression was found in 19.4% of benign and 93.1% of PTC samples. For the diagnosis of PTC for CXCL12 staining of FNA specimens, the calculated values were 93.1% sensitivity, 90.3% specificity, 94.7% positive predictive value, 87.5% negative predictive value, and 89.1% accuracy. CXCL12 had 100% sensitivity and specificity for the 12 cases of atypia of undetermined significance (AUS) diagnosed in FNA specimens. Conclusions: CXCL12 may be a useful diagnostic tool for PTC, especially when the FNA specimen is classified as AUS.


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