Indian Journal of Pathology and Microbiology
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Year : 2020  |  Volume : 63  |  Issue : 4  |  Page : 604-607

Palisaded encapsulated neuroma in tongue – A commonly misdiagnosed peripheral nerve sheath tumor

1 Department of Surgery, Stomatology, Pathology and Radiology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil
2 University of Sao Joao Del Rei, Campus Centro-Oeste Dona Lindu, Divinopolis, Minas Gerais, Amazonas, Brazil
3 Department of Dentistry, Amazon Faculty, IAES, Manaus, Amazonas, Brazil
4 Department of Pathology, Lauro de Souza Lima Institute, Bauru, Brazil

Correspondence Address:
Denise T Oliveira
Bauru School of Dentistry, Department of Surgery, Stomatology, Pathology and Radiology, Area of Pathology, Alameda Octavio Pinheiro Brisolla, 9-75 CEP 17012-901, Bauru, Sao Paulo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPM.IJPM_515_19

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Palisaded encapsulated (solitary circumscribed) neuromas are benign neural tumors, rarely found in oral mucosa. This case reports a 24-year-old man that presented a unique soft nodule at the left side of the tongue. An excisional biopsy was performed under local anesthesia and histopathological examination of the surgical specimen revealed a well circumscribed mass composed of spindled Schwann cells, often aligned and fasciculated, forming occasional nodules embedded in a fibrous stroma. Histopathological analysis showed the presence of positive cells for S-100, EMA, CD57, and collagen IV. Based on clinical and microscopical features, the diagnosis established was of palisaded encapsulated neuroma. This case report aims to discuss the differential diagnosis among palisaded encapsulated neuroma and the other neural tumors that affect the oral mucosa.

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