Indian Journal of Pathology and Microbiology
Home About us Instructions Submission Subscribe Advertise Contact e-Alerts Ahead Of Print Login 
Users Online: 755
Print this page  Email this page Bookmark this page Small font sizeDefault font sizeIncrease font size
Year : 2021  |  Volume : 64  |  Issue : 2  |  Page : 362-368

Clinical characteristics and gene mutation analysis of clear cell tumor of the lung

1 Department of Respiratory Medicine, Lihuili Hospital, Ningbo Medical Center, Ningbo, China
2 Department of Diagnosis, Ningbo Diagnostic Pathology Center, Ningbo, China
3 Department of Medical Imaging, Lihuili Hospital, Ningbo Medical Center, Ningbo, China
4 Department of Cardio-Thoracic, Lihuili Hospital, Ningbo Medical Center, Ningbo, China
5 Department of Radiation Oncology, Lihuili Hospital, Ningbo Medical Center, Ningbo, China

Correspondence Address:
Kaitai Liu
Department of Radiation Oncology, Lihuili Hospital, Ningbo Medical Center, Ningbo . 315041, China; No. 57, Xingning Road, Ningbo 315041
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPM.IJPM_65_19

Rights and Permissions

There were rare clinical reports on clear cell tumor of the lung (CCTL). The clinical characteristics and underlying genetic mutation status of CCTL are poorly understood. From 2012 to 2017, patients pathologically diagnosed with CCTL in our hospital were investigated and analyzed based on clinical manifestations, pathological characteristics, prognosis and full gene mutation status through next generation sequencing (NGS) technology. During a 6-year period, four eligible patients were diagnosed with CCTL through surgical resection and were included in this study. All patients showed solitary nodules or lumps located in the left lung. The average maximum diameter of lesions was 2.5 ± 1.1 cm. Computed tomography (CT) imaging characteristics of these nodules/lumps demonstrated the features of benign tumors. The hematoxylin-eosin (HE) morphology and immunohistochemistry were consistent with the histopathological features of benign CCTL. Subsequent NGS analysis showed frame shift mutations of F2421/E2419, K1466E mutation, and p. 1450_1456 deletion mutation in mTOR gene in two of four patient samples and amplifications of MCL1 were observed in three of four samples. CCTL is a rare type of primary pulmonary mesenchymal tumor with good prognosis. Preliminary diagnosis on CT is usually sclerosing pneumocytoma. It is still unclear whether the occurrence and development of the disease are related to specific gene mutation. In this study, the genomic findings of frame shift mutation of mTOR genes and amplification of MCL1 gene in CCTL suggest that these mutations might play a role in proliferation of CCTL.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded2    
    Comments [Add]    

Recommend this journal