Indian Journal of Pathology and Microbiology
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Year : 2021  |  Volume : 64  |  Issue : 2  |  Page : 382-384

Rhabdomyolysis with myoglobin-induced acute kidney injury: A case series of four cases

1 Department of Nephrology, Government Kilpauk Medical College, Chennai, Tamil Nadu, India
2 Renopath, Center for Renal and Urological Pathology, Chennai, Tamil Nadu, India

Correspondence Address:
Hanock Unni Samuel
Department of Nephrology, Government Kilpauk Medical College, Kilpauk, Chennai, Tamil Nadu-600 010
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPM.IJPM_89_20

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Rhabdomyolysis is a potentially life-threatening clinical syndrome characterized by the breakdown of skeletal muscle cells and release of creatine kinase (CK), lactate dehydrogenase (LDH), and myoglobin into the plasma and interstitial space. Rhabdomyolysis can occur due to a variety of causes and acute kidney injury (AKI) is one of its most dreaded complications occurring in 33%–50% patients. The main pathophysiology of renal injury is due to vasoconstriction, intraluminal casts, tubular obstruction, and direct myoglobin toxicity. As the symptoms are nonspecific, a high level of suspicion is required in the mind of the treating physician. Early diagnosis and prompt management with fluid resuscitation, initiation of renal replacement therapy (RRT), and elimination of causative agents can help prevent complications. We hereby report four interesting cases of this clinical syndrome with emphasis on the causative agents.

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