LGCmain
Indian Journal of Pathology and Microbiology
Home About us Instructions Submission Subscribe Advertise Contact e-Alerts Ahead Of Print Login 
Users Online: 656
Print this page  Email this page Bookmark this page Small font sizeDefault font sizeIncrease font size
CASE REPORT
Year : 2021  |  Volume : 64  |  Issue : 2  |  Page : 394-397

Malignant transformation of monostotic fibrous dysplasia into angiosarcoma in the proximal tibia


1 Department of Surgical Pathology, Uludag University, Faculty of Medicine, Uludag University, Bursa, Turkey
2 Department of Orthopaedics and Traumatology, Uludag University, Faculty of Medicine, Uludag University, Bursa, Turkey
3 Department of Radiology, Faculty of Medicine, Uludag University, Bursa, Turkey

Correspondence Address:
Selin Narter
Department of Surgical Pathology, Uludag University, Faculty of Medicine, 16059, Gorukle, Bursa
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJPM.IJPM_897_20

Rights and Permissions

The majority of bone angiosarcomas are primary tumors while secondary angiosarcomas arise after radiation therapy or bone infarctus. This article presents a case of malignant transformation of monostotic fibrous dysplasia into angiosarcoma. An 80-year-old female presented with pain on right cruris. Radiological examination revealed a lesion with lytic areas and destruction of cortical bone on right tibia. Gross and histopathological examination showed two areas with an abrupt transition. The solid component was composed of curved, immature bony trabeculae in a fibroblastic stroma. The other component involved epitheloid cells forming slit-like vascular spaces. The diagnosis of angiosarcoma and fibrous dysplasia was given. Malignant transformation of fibrous dysplasia into angiosarcoma is extremely rare; as this is the sixth case in the existing literature. Prognosis of fibrous dysplasia is generally good and less than 1% of the patients develop a malignant tumor. Therefore, patients with fibrous dysplasia should be offered a life-long follow-up.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed126    
    Printed0    
    Emailed0    
    PDF Downloaded2    
    Comments [Add]    

Recommend this journal