Indian Journal of Pathology and Microbiology


Year
: 1995  |  Volume : 38  |  Issue : 4  |  Page : 383--8

Role of AgNORs in diagnosis of early malignant lesions of gall bladder.


V Misra, S P Misra, M Dwivedi, S C Gupta 
 Department of Pathology and Gastoenterology, M.L.N. Medical College, Allahabad

Correspondence Address:
V Misra
Department of Pathology and Gastoenterology, M.L.N. Medical College, Allahabad

Sections from eighty nine specimens of gall bladder including 40 cases of chronic cholecystitis, 9 dysplasia 15 well differentiated adenocarcinoma, 14 moderately differentiated adenocarcinoma and 11 poorly differentiated adenocarcinomas were studied for argyrophilic nucleolar organizer regions (AgNOR«SQ»s). The difference between mean +/- SD NOR counts of chronic cholecystitis (1.97 +/- 0.28), dysplasia (5.6 +/- 0.88) well differentiated adenocarcinoma (7.2 +/- 0.30) and moderately differentiated adenocarcinoma (8.0 +/- 0.63) was statistically significant (p < 0.001). NOR counts of poorly differentiated adenocarcinoma (8.5 +/- 0.78) were higher than moderately differentiated carcinoma but the difference was not statistically significant. Despite the significant difference in the mean values, a considerable overlap in the NOR counts of individual cases of different groups was observed suggesting that though NOR counts can not act as a specific diagnostic parameter for diagnosis of early carcinoma and dysplasia in isolated cases, they may prove to be a good adjunct to already existing parameters like imaging techniques or cytology.


How to cite this article:
Misra V, Misra S, Dwivedi M, Gupta S. Role of AgNORs in diagnosis of early malignant lesions of gall bladder. Indian J Pathol Microbiol 1995;38:383-8


How to cite this URL:
Misra V, Misra S, Dwivedi M, Gupta S. Role of AgNORs in diagnosis of early malignant lesions of gall bladder. Indian J Pathol Microbiol [serial online] 1995 [cited 2022 Aug 11 ];38:383-8
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=1995;volume=38;issue=4;spage=383;epage=8;aulast=Misra;type=0