Indian Journal of Pathology and Microbiology


Year
: 1997  |  Volume : 40  |  Issue : 3  |  Page : 303--7

Detection of anti-PPD IgG antibody and PPD-induced delayed type hypersensitivity in anterior uveitis patients.


A K Kapoor, R Gopal, B Lal, O P Asthana, P K Agarwal, K Mukerjee, R P Saxena, P Dhawan 
 Department of Pathology, K.G. Medical College, Lucknow

Correspondence Address:
A K Kapoor
Department of Pathology, K.G. Medical College, Lucknow

Present study relates to the results of anti-PPD IgG, anti-A60 and antinuclear antibodies and PPD-induced delayed type hypersensitivity (DTH) in 17 anterior uveitis, (AU) patients. Results of anti-PPD IgG assay revealed detection of higher mean antibody level (O.D. 0.11 +/- 0.06) compared to healthy controls (O.D. 0.04 +/- 0.03), other eye disease controls (O.D. 0.05 +/- 0.003) and leprosy controls (O.D. 0.03 +/- 0.03). Anti-A60 IgM antibody assay revealed insignificant differences in mean antibody levels between various groups. Four of 17(23.5%) AU patients and 1(5.8%) subject each, belonging to other eye disease and healthy control groups had raised anti-nuclear antibody index. Findings of PPD skin test revealed detection of moderate to strong (2 to 4+) reactivity in 14 (82%). AU patients. Conversely, 13(76%) healthy controls and 8(47%) other eye disease controls gave mild (1+) reactivity. Results of this study suggested possible role of hypersensitivity to mycobacterial antigens in pathogenesis of anterior uveitis.


How to cite this article:
Kapoor A, Gopal R, Lal B, Asthana O, Agarwal P, Mukerjee K, Saxena R, Dhawan P. Detection of anti-PPD IgG antibody and PPD-induced delayed type hypersensitivity in anterior uveitis patients. Indian J Pathol Microbiol 1997;40:303-7


How to cite this URL:
Kapoor A, Gopal R, Lal B, Asthana O, Agarwal P, Mukerjee K, Saxena R, Dhawan P. Detection of anti-PPD IgG antibody and PPD-induced delayed type hypersensitivity in anterior uveitis patients. Indian J Pathol Microbiol [serial online] 1997 [cited 2021 Nov 30 ];40:303-7
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=1997;volume=40;issue=3;spage=303;epage=7;aulast=Kapoor;type=0