Indian Journal of Pathology and Microbiology


Year
: 2000  |  Volume : 43  |  Issue : 2  |  Page : 147--54

Gall stones and carcinoma gall bladder.


S C Gupta, V Misra, P A Singh, A Roy, S P Misra, A K Gupta 
 Department of Pathology, M.L.N. Medical College, Allahabad

Correspondence Address:
S C Gupta
Department of Pathology, M.L.N. Medical College, Allahabad

One hundred and fifty surgically resected gall bladder specimens were included in the study to evaluate the relationship between the prevalence of gall stones and histochemical alteration in sequential changes of metaplasia, dysplasia and neoplasia in gall bladder epithelium. Multiple sections were processed and stained with haematoxylin and eosin, Periodic acid Schiff«SQ»s stain, Alcian blue (pH 2.5)/Periodic acid, Orcein/Alcian blue (pH 2.5) and Alcian Blue/Periodic acid/Potassium borohydride saponifications stains. Details of gall stones present were also noted. Prevalence of gall stones in gall bladders with metaplastic, dysplastic and neoplastic mucosal changes was significantly higher (P < 0.001) than those gall bladders which had no epithelial changes. Increase in sialomucin with a corresponding decrease in sulphomucin was observed from metaplasia to malignancy. Neutral mucin increased in metaplastic cells but was significantly reduced in neoplastic cells. Loss of O-acylation in sialmucin was also present in neoplastic cells. The histochemical changes suggest that chronic injury due to cholelithiasis induces appearance of neutral mucin positive metaplastic cells, which may further dedifferentiate to sialomucin containing dysplastic or neoplastic cells if the stimulation persists.


How to cite this article:
Gupta S, Misra V, Singh P, Roy A, Misra S, Gupta A. Gall stones and carcinoma gall bladder. Indian J Pathol Microbiol 2000;43:147-54


How to cite this URL:
Gupta S, Misra V, Singh P, Roy A, Misra S, Gupta A. Gall stones and carcinoma gall bladder. Indian J Pathol Microbiol [serial online] 2000 [cited 2021 Jan 19 ];43:147-54
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2000;volume=43;issue=2;spage=147;epage=54;aulast=Gupta;type=0