Indian Journal of Pathology and Microbiology


Year
: 2001  |  Volume : 44  |  Issue : 1  |  Page : 9--12

A study of the haematologic spectrum of myelodysplastic syndrome.


J Kini, U N Khadilkar, J P Dayal 
 Department of Pathology, Kottayam Medical College, Kottayam

Correspondence Address:
J Kini
Department of Pathology, Kottayam Medical College, Kottayam

In 31 patients of myelodysplastic syndrome, RAEB-t was the commonest subtype (29%), and RARS, the lease common (6.4%); 19.4% were characterised as the unclassifiable (UC) group. Pallor was the dominant sign (90.3%). Low haemoglobin in RA & RARS (p<0.05), thrombocytopenia in RAEB-t (p<0.01) and high leuco/monocyte counts in CMML (p<0.001) were observed. Neutropenia occurred most frequently in RAEB & RAEB-t and circulating blasts in all cases of RAEB-t and CMML. Bicytopenia was the commonest finding (58.1%) and pancytopenia the least (16.1%). 84% of marrows were hypercellular and trilineage dysplasia was seen in 68% of patients. Megaloblastoid dyserythropoiesis was the predominant feature in all cases, dysgranulopoiesis in all cases of RAEB, RAEB-t and CMML, and micromegokaryocytes in all cases of RARS, RAEB & CMML were seen. RAEB-t and RAEB (33.3% each) were the predominant groups which progressed to leukemia, FAB AML-M2, being the commonest type (60%).


How to cite this article:
Kini J, Khadilkar U, Dayal J. A study of the haematologic spectrum of myelodysplastic syndrome. Indian J Pathol Microbiol 2001;44:9-12


How to cite this URL:
Kini J, Khadilkar U, Dayal J. A study of the haematologic spectrum of myelodysplastic syndrome. Indian J Pathol Microbiol [serial online] 2001 [cited 2021 Jun 21 ];44:9-12
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2001;volume=44;issue=1;spage=9;epage=12;aulast=Kini;type=0