Indian Journal of Pathology and Microbiology


Year
: 2006  |  Volume : 49  |  Issue : 3  |  Page : 376--80

Utility of galectin 3 expression in thyroid aspirates as a diagnostic marker in differentiating benign from malignant thyroid neoplasms.


M Aron, K Kapila, K Verma 
 Department of Pathology, All India Institute of Medical Sciences, New Delhi

Correspondence Address:
M Aron
Department of Pathology, All India Institute of Medical Sciences, New Delhi

Galectin-3 is a 31kD beta-galactoside binding lectin, which is known to be expressed in various neoplasms including thyroid tumors. This study was conducted to study the role of galectin-3 in differentiating benign from malignant thyroid nodules onfine needle aspirates (FNAC). Galectin-3 immuocytochemistry was performed in 70 cases with adequate smears. The cytology diagnosis of these cases was: papillary carcinoma (25), follicular neoplasm (16), adenomatous goiter (20), hyperplastic nodule (5), medullary carcinoma (5) and anaplastic carcinoma (1). Galectin-3 positivity was seen in 80% of papillary carcinomas, 37.5% offollicular neoplasms and in 60% of benign nodules. The single case of anaplastic carcinoma was positive but all the cases of medullary carcinoma were negativefor galectin-3. Three of thefollicular neoplasms that were diagnosed on histology as carcinoma were positive on cytology and one case offollicular adenoma was also positive. Our study shows that galectin-3 is strongly expressed in smears of papillary carcinoma. However, since it is also expressed in a variety of benign lesions, its role as a pre-surgical markerfor differentiating benignfrom malignant thyroid nodules is limited.


How to cite this article:
Aron M, Kapila K, Verma K. Utility of galectin 3 expression in thyroid aspirates as a diagnostic marker in differentiating benign from malignant thyroid neoplasms. Indian J Pathol Microbiol 2006;49:376-80


How to cite this URL:
Aron M, Kapila K, Verma K. Utility of galectin 3 expression in thyroid aspirates as a diagnostic marker in differentiating benign from malignant thyroid neoplasms. Indian J Pathol Microbiol [serial online] 2006 [cited 2021 Jan 19 ];49:376-80
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2006;volume=49;issue=3;spage=376;epage=80;aulast=Aron;type=0