Indian Journal of Pathology and Microbiology


Year
: 2007  |  Volume : 50  |  Issue : 1  |  Page : 94--6

Induction of resistance to fluoroquinolones in clinical and environmental isolates of Pseudomonas aeruginosa.


S Vishnu Prasad, M Ballal, PG Shivananda 
 Department of Microbiology, Kasturba Medical College, Manipal and Sikkim Institute of Medical Sciences, Gangtok, Sikkim

Correspondence Address:
S Vishnu Prasad
Department of Microbiology, Kasturba Medical College, Manipal and Sikkim Institute of Medical Sciences, Gangtok, Sikkim

An attempt to induce resistance to ciprofloxacin in vitro was made against clinical and environmental isolates of Pseudomonas aeruginosa. This in vitro manipulation of strains resulted in the increase of minimum inhibitory concentration from 0.4 microg/ml to 1 microg/ml of the original strains to 9.0 to 12.5 microg/ml indicating development of resistance to ciprofloxacin and a major decrease in the size of zone diameters of norfloxacin and ofloxacin indicating cross resistance to these agents. Results indicate the induced resistance to ciprofloxacin can promote development of cross resistance to other fluoroquinolones. This suggests that caution should be taken while using fluoroquinolones for the treatment of Pseudomonas aeruginosa infections.


How to cite this article:
Prasad S V, Ballal M, Shivananda P G. Induction of resistance to fluoroquinolones in clinical and environmental isolates of Pseudomonas aeruginosa. Indian J Pathol Microbiol 2007;50:94-6


How to cite this URL:
Prasad S V, Ballal M, Shivananda P G. Induction of resistance to fluoroquinolones in clinical and environmental isolates of Pseudomonas aeruginosa. Indian J Pathol Microbiol [serial online] 2007 [cited 2021 Jun 24 ];50:94-6
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2007;volume=50;issue=1;spage=94;epage=6;aulast=Prasad;type=0