Indian Journal of Pathology and Microbiology


Year
: 2007  |  Volume : 50  |  Issue : 3  |  Page : 636--9

Multimeric analysis in diagnosis of vWD variants in Indians.


PK Gupta, H Kumar, R Saxena 
 Department of Transfusion Medicine, Armed Forces Medical College, Pune

Correspondence Address:
P K Gupta
Department of Transfusion Medicine, Armed Forces Medical College, Pune

von Willebrand disease is a common inherited bleeding disorder and the problem is undefined in developing countries due to limitation of its diagnostic facilities. The aim of the study was to diagnose vWD in patients with history of muco - cutaneous bleeding and characterization into its variants by multimeric analysis. 224 patients presenting with history of muco - cutaneous bleeding were selected. In all patients, platelet count, BT, PT, APTT, PF3 availability, clot solubility and factor VIII assay were done. Diagnosis of vWD was confirmed by RIPA, vWF: Ag, and vWF: RCo and its sub-characterization was done by multimeric analysis. 64 patients were diagnosed to have vWD. Of these, 21.9% were of type 1 vWD, 43.7% type 2 vWD, 1.6% acquired vWD and 32.8% type 3 vWD. By multimeric analysis, 2 patients had supranormal HMW multimers and two patients had normal distribution of vWF multimers were diagnosed as type 2M «SQ»Vicenza«SQ»; and type 2M vWD respectively. It is concluded, that vWD is not an uncommon condition amongst Indian population.


How to cite this article:
Gupta P K, Kumar H, Saxena R. Multimeric analysis in diagnosis of vWD variants in Indians. Indian J Pathol Microbiol 2007;50:636-9


How to cite this URL:
Gupta P K, Kumar H, Saxena R. Multimeric analysis in diagnosis of vWD variants in Indians. Indian J Pathol Microbiol [serial online] 2007 [cited 2020 Dec 2 ];50:636-9
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2007;volume=50;issue=3;spage=636;epage=9;aulast=Gupta;type=0