Indian Journal of Pathology and Microbiology

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 53  |  Issue : 3  |  Page : 470--475

Comparison of FibroTest-ActiTest with histopathology in demonstrating fibrosis and necroinflammatory activity in chronic hepatitis B and C


Cemile Uyar1, Fusun Zeynep Akcam1, Metin Ciris2, Onur Kaya1, Cem Kockar3, Mehmet Isler3 
1 Department of Infectious Diseases, Suleyman Demirel Universty Medical Education and Research Hospital, Isparta, Turkey
2 Department of Pathology, Suleyman Demirel Universty Medical Education and Research Hospital, Isparta, Turkey
3 Department of Gastroenterology, Suleyman Demirel Universty Medical Education and Research Hospital, Isparta, Turkey

Correspondence Address:
Fusun Zeynep Akcam
Department of Infectious Diseases, Suleyman Demirel University Medical Education and Research Hospital, Isparta-32260
Turkey

Aims: FibroTest and ActiTest are noninvasive tests used in determining the level of fibrosis and the degree of necroinflammatory activity in the liver. In our study, we aimed to investigate whether these tests could be alternative to liver biopsy. Materials and Methods: Fifty patients were included in the study. Serum samples were obtained and liver needle biopsy was performed on the same day. Levels of fibrosis in FibroTest and levels of activity in ActiTest, both determined via serum biochemical markers, were compared with levels of fibrosis and activity in histopathological examination. For statistical analyses, Mc Nemar chi square test and Spearman«SQ»s correlation tests were used. Results: There was a significant positive correlation between fibrosis in biopsy and the level of fibrosis in FibroTest in patients with hepatitis B virus (HBV) (rho: 0.67, P < 0.0001). However, no significant correlation was determined between the activity in biopsy and the degree of activity in ActiTest (rho: 0.29, P < 0.05). No significant correlation was determined between both fibrosis and activity established in biopsy and the results of FibroTest and ActiTest in the group of patients with hepatitis C virus (HCV) (rho: 0.22, P < 0.05 and rho: 0.15, P < 0.05, respectively). Conclusion: Our results suggest that novel and safer noninvasive biochemical tests are needed as an alternative to histopathology in patients infected with HBV and HCV. Consequently, we believe that liver biopsy maintains its place as a gold standard in determining the histopathological condition of the liver.


How to cite this article:
Uyar C, Akcam FZ, Ciris M, Kaya O, Kockar C, Isler M. Comparison of FibroTest-ActiTest with histopathology in demonstrating fibrosis and necroinflammatory activity in chronic hepatitis B and C.Indian J Pathol Microbiol 2010;53:470-475


How to cite this URL:
Uyar C, Akcam FZ, Ciris M, Kaya O, Kockar C, Isler M. Comparison of FibroTest-ActiTest with histopathology in demonstrating fibrosis and necroinflammatory activity in chronic hepatitis B and C. Indian J Pathol Microbiol [serial online] 2010 [cited 2021 Sep 23 ];53:470-475
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=3;spage=470;epage=475;aulast=Uyar;type=0