Indian Journal of Pathology and Microbiology

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 54  |  Issue : 1  |  Page : 21--24

A cytohistological study of Ki-67 expression in ovarian tumors


Monisha Choudhury, Seema Goyal, Mukta Pujani 
 Department of Pathology, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi, India

Correspondence Address:
Mukta Pujani
Department of Pathology, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi - 110 001
India

Background and Objective: The study was conducted to evaluate the diagnostic accuracy of imprint cytology in ovarian neoplasms, and to investigate the biological significance of Ki-67 antigen expression in benign and malignant ovarian tumors and correlate it with histological type, grade, and stage of malignant tumor. Materials and Methods: A total of 50 cases including 25 prospective and 25 retrospective cases were studied. Imprint cytology was performed on 25 ovarian tumors and compared with histopathological diagnosis. Ki-67 immunohistochemistry was performed on all 50 cases. Results: On immunohistochemistry, benign tumors had a mean Ki-67 index of 3.2 ± 3.7 while malignant tumors had a mean Ki-67 index of 33.1 ± 16.7, the difference being statistically significant. Significant correlation was observed between the Ki-67 index and stage of the tumor; however, there was no correlation between the grade of differentiation and histological type of tumor with the Ki-67 index. Conclusions: In the present study, the Ki-67 index was higher in advanced stage tumors; hence a higher Ki-67 index points toward the aggressive behavior and poorer clinical outcomes.


How to cite this article:
Choudhury M, Goyal S, Pujani M. A cytohistological study of Ki-67 expression in ovarian tumors.Indian J Pathol Microbiol 2011;54:21-24


How to cite this URL:
Choudhury M, Goyal S, Pujani M. A cytohistological study of Ki-67 expression in ovarian tumors. Indian J Pathol Microbiol [serial online] 2011 [cited 2022 May 27 ];54:21-24
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=1;spage=21;epage=24;aulast=Choudhury;type=0