Indian Journal of Pathology and Microbiology

: 2012  |  Volume : 55  |  Issue : 2  |  Page : 256-

Hamazaki-Wesenberg bodies in mesenteric lymph node

Vandana L Gaopande, Sanjay D Deshmukh 
 Department of Pathology, Smt Kashibai Navale Medical College, Pune, Maharashtra, India

Correspondence Address:
Vandana L Gaopande
Department of Pathology, Smt Kashibai Navale Medical College, Narhe (Ambegaon), Off Katraj Bypass Highway, Pune - 411 042, Maharashtra

How to cite this article:
Gaopande VL, Deshmukh SD. Hamazaki-Wesenberg bodies in mesenteric lymph node.Indian J Pathol Microbiol 2012;55:256-256

How to cite this URL:
Gaopande VL, Deshmukh SD. Hamazaki-Wesenberg bodies in mesenteric lymph node. Indian J Pathol Microbiol [serial online] 2012 [cited 2022 Jul 2 ];55:256-256
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Presenting a case where, Hamazaki-Wesenberg bodies were found in the mesenteric lymph node. Their importance lies in their being confused with fungi or pigment.

A 60-year-old female presented with distension of abdomen of four days duration. General examination did not reveal any significant signs. Per abdominal examination revealed a distended soft abdomen. There was no free fluid. Routine hematological and biochemical investigations were normal. An exploratory laparotomy revealed dilated, fluid, and gas filled loops of small intestine. The large intestine was dilated up to the splenic flexure. The dilated bowel was squeezed, emptied, and the contents aspirated. There was no evidence of growth or stricture. No evidence of bile leakage was seen. Enlarged mesenteric lymph node was excised. Microscopic examination of the lymph node showed sinus hystiocytosis with hyperplasia of lymphoid follicles. Within the sinusoids were seen round to oval brown colored structures lying loose or within the cytoplasm of hystiocytes. [Figure 1]. Their sizes varied from about equal to an RBC or double its size. At places, they had pointed ends, while rounded ends were seen at other places. These structures were Periodic acid Schiff negative. These structures were negative for bile pigment and hemosiderin pigment on special staining. In phosphotungstic acid hematoxyline stain, they took black color. These bodies were interpreted as Hamazaki-Wesenberg bodies.{Figure 1}


Hamazaki-Wesenberg bodies were first described by Hamazaki in 1938. Tudway [1] in his study found Hamazaki-Wesenberg (HW) bodies in 22.8% of the 359 lymph nodes collected from 46 necropsies. They are more commonly found in the mesenteric lymph nodes (35.6%). [1] They are also found in other lymph node groups like mediastinal, para-aortic, axillary, inguinal etc. [1] Histochemically they are found to be similar to lipofuchsin. [1] They are not found to be significantly common at any age or in any sex. [1] Also, there is no significant relation between the presence of HW bodies and any specific disease. [1]

The importance of HW bodies lies in their resemblance to fungal bodies and/or pigment.


1Tudway AJ. Yellow bodies in superficial and deep lymph nodes. J Clin Pathol 1979;32:52-5.