Indian Journal of Pathology and Microbiology

CASE REPORT
Year
: 2012  |  Volume : 55  |  Issue : 4  |  Page : 574--577

CD34 positive-microgranular variant of acute promyelocytic leukemia in a child


Ashwini R Nargund1, Geeta V Patil1, CP Raghuram2, Eswarachary Venkataswamy1 
1 Department of Molecular Biology, R & D, Triesta Reference Laboratory, HCG, Bangalore, Karnataka, India
2 Department of Paediatric Oncology, Health Care Global Enterpreises, Bangalore, Karnataka, India

Correspondence Address:
Ashwini R Nargund
E-204, Purva Fairmont Apartments, Parangipalya, Bangalore, Karnataka
India

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. APL is rare in children (approximately 10% of childhood AML) and is characterized by a higher incidence of hyperleukocytosis, an increased incidence of microgranular morphology, the presence of balanced t(15;17)(q22;q11.2-12) translocation, and more frequent occurrence of the PML-RARα isoforms bcr 2 and bcr 3 compared to adults. The cytomorphology of microgranular variant blasts is obviously different from AML M3 blasts; these cells have a nongranular or hypogranular cytoplasm or contain fine dust-like cytoplasmic azurophil granules that may not be apparent by light microscopy. This case report emphasizes the importance of a high index of suspicion for the diagnosis of APL, the hypogranular variant in particular. They are responsive to differentiation therapy with all trans-retinoic acid and complete remission in seen in >80% cases.


How to cite this article:
Nargund AR, Patil GV, Raghuram C P, Venkataswamy E. CD34 positive-microgranular variant of acute promyelocytic leukemia in a child.Indian J Pathol Microbiol 2012;55:574-577


How to cite this URL:
Nargund AR, Patil GV, Raghuram C P, Venkataswamy E. CD34 positive-microgranular variant of acute promyelocytic leukemia in a child. Indian J Pathol Microbiol [serial online] 2012 [cited 2020 Oct 24 ];55:574-577
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=4;spage=574;epage=577;aulast=Nargund;type=0