Indian Journal of Pathology and Microbiology

LETTER TO EDITOR
Year
: 2014  |  Volume : 57  |  Issue : 1  |  Page : 161--162

Chronic lymphocytic leukemia developing in a case of chronic myelogenous leukemia: Some observations


Mayur Parihar1, Neeraj Arora2, Deepak Kumar Mishra2,  
1 Department of Cytogenetics and Laboratory Hematology, Lab Haematology, Tata Medical Center, Kolkata, West Bengal, India
2 Department of Cytogenetics and Laboratory Hematology, Laboratory Hematology, Tata Medical Center, Kolkata, West Bengal, India

Correspondence Address:
Mayur Parihar
Department of Cytogenetics, Tata Medical Center, Kolkata - 700 156, West Bengal
India




How to cite this article:
Parihar M, Arora N, Mishra DK. Chronic lymphocytic leukemia developing in a case of chronic myelogenous leukemia: Some observations.Indian J Pathol Microbiol 2014;57:161-162


How to cite this URL:
Parihar M, Arora N, Mishra DK. Chronic lymphocytic leukemia developing in a case of chronic myelogenous leukemia: Some observations. Indian J Pathol Microbiol [serial online] 2014 [cited 2021 Sep 24 ];57:161-162
Available from: https://www.ijpmonline.org/text.asp?2014/57/1/161/130942


Full Text

Sir,

We read with interest the case report titled "Chronic lymphocytic leukemia developing in a case of chronic myelogenous leukemia accelerated phase: A rare case with review of the literature" by Kumar et al. in the July September edition of IJPM. We would like to share some observations in this interesting case.

The case report describes a 44 year female with 46, XX, t (9; 22)(q34; q11) subsequently developing a chronic lymphocytic leukemia, but the karyotype picture in [Figure 2] actually shows a karyogram with a male karyotype 46,XY. We would request the authors to clarify whether the patient had any sexual ambiguity with a female phenotype and a male karyotype with a 46, XY image.

The standard International Society of Cytogenetic Nomenclature has not been followed in describing the karyogram. Furthermore, there appears to be an error in the placement and identification of chromosomes in the karyotype image. Both the homologues of chromosomes 8 have been wrongly placed under the chromosome 9 and the actual chromosomes 9 under the chromosomes 8, hence questioning the presence of t (9;22) in this patient. Keeping in mind the ambiguity of the presence of t (9;22) in the karyotype image we would request the authors to mention the type of fusion transcript found in the reverse transcription polymerase chain reaction.

We also request the authors to share bone marrow biopsy findings for CD20 at the time of diagnosis of chronic myelogenous leukemia.