Indian Journal of Pathology and Microbiology

BRIEF COMMUNICATION
Year
: 2014  |  Volume : 57  |  Issue : 1  |  Page : 78--80

Your dilemma, my identity: Unusual immunogenetic profiles of pediatric B cell acute lymphoblastic leukemia


Anurag Gupta1, Manu Goyal1, Koteswara Rao Nidamanuri1, Palanki Satya Dattatreya2 
1 Department of Hematopathology, AmPath, American Oncology Institute and Citizens Hospital, Hyderabad, Andhra Pradesh, India
2 Department of Medical Oncology, Omega Hospital, Hyderabad, Andhra Pradesh, India

Correspondence Address:
Manu Goyal
Department of Hematopathology, AmPath, American Oncology Institute and Citizens Hospital, Hyderabad, Andhra Pradesh
India

B-cell acute lymphoblastic leukemia (B-ALL) is characterized by CD19 expression, which is one of the most important prerequisites, along with expression of CD10, CD22 and/or CD79a. Rearrangements involving MLL gene are seen in CD10 B-ALL (pro-B cell origin) and t(9;11)(p21;q23) is most commonly reported in acute myeloid leukemia (AML), where it is known to carry very good prognosis in pediatric AMLs and rarely in acute lymphoblastic leukemia (ALL). We report a case of CD10 + , CD19 pediatric ALL with rearrangements of MLL gene as a result of t(9;11)(p21;q23), thus conferring a very poor prognosis. The case emphasizes use of comprehensive panel of antibodies for flow cytometric immunophenotyping and cytogenetic correlation for correct diagnosis and prognostication.


How to cite this article:
Gupta A, Goyal M, Nidamanuri KR, Dattatreya PS. Your dilemma, my identity: Unusual immunogenetic profiles of pediatric B cell acute lymphoblastic leukemia.Indian J Pathol Microbiol 2014;57:78-80


How to cite this URL:
Gupta A, Goyal M, Nidamanuri KR, Dattatreya PS. Your dilemma, my identity: Unusual immunogenetic profiles of pediatric B cell acute lymphoblastic leukemia. Indian J Pathol Microbiol [serial online] 2014 [cited 2021 Sep 22 ];57:78-80
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2014;volume=57;issue=1;spage=78;epage=80;aulast=Gupta;type=0