Indian Journal of Pathology and Microbiology

: 2014  |  Volume : 57  |  Issue : 4  |  Page : 642-

Quiz 6/ 2014

KP Aravindan 
 Professor of PathologyGovt Medical College Kozhikode, Kerala, India

Correspondence Address:
K P Aravindan
Professor of PathologyGovt Medical College Kozhikode, Kerala

How to cite this article:
Aravindan K P. Quiz 6/ 2014.Indian J Pathol Microbiol 2014;57:642-642

How to cite this URL:
Aravindan K P. Quiz 6/ 2014. Indian J Pathol Microbiol [serial online] 2014 [cited 2021 Dec 8 ];57:642-642
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Full Text

Direct immunofluorescence of a skin biopsy (Anti IgG).


Pemphigus erythematosus: The picture shows the classic fish-net appearance due to the deposition of anti-IgG antibody around the epidermal cells. But, in addition, there is also a granular deposit all along the basement membrane zone.[1],[2] This combination is characteristic of a variant of pemphigus foliaceus named pemphigus eryhtematosus. It is characterized by subcorneal blistering and intraepidermal deposition of IgG antibodies that bind the desmosomal cadherin desmoglein 1 (Dsg1). It was was first described in 1926 by Senear and Usher as a condition with a lupus like butterfly rash, which they suggested was a combination of pemphigus vulgaris and lupus erythematosus (LE). [3]

Paraneoplastic pemphigus is another lesion which on occasion can have this combination of epidermal and basement membrane zone deposition of IgG. Antibodies against plakin proteins are present in the serum and there is an underlying lymphoproliferative disorder in most of these cases.


1Chorzelski T, Jabloñska S, Blaszczyk M. Immunopathological investigations in the Senear-Usher syndrome (coexistence of pemphigus and lupus erythematosus). Br J Dermatol. 1968;80:211-7.
2Amerian ML, Ahmed AR. Pemphigus erythematosus. Senear-Usher syndrome. Int J Dermatol. 1985;24:16-25.
3Oktarina DA, Poot AM, Kramer D, Diercks GF, Jonkman MF, Pas HH. The IgG "lupus-band" deposition pattern of pemphigus erythematosus: Association with the desmoglein 1 ectodomain as revealed by 3 cases. Arch Dermatol. 2012;148:1173-8.