Indian Journal of Pathology and Microbiology

: 2015  |  Volume : 58  |  Issue : 1  |  Page : 133-

Color Atlas of Tissue Response to Biomaterials

KP Aravindan 
 Department of Pathology, Government of Medical College, Kozhikode, Kerala, India

Correspondence Address:
Prof. K P Aravindan
Department of Pathology, Government of Medical College, Kozhikode, Kerala

How to cite this article:
Aravindan K P. Color Atlas of Tissue Response to Biomaterials.Indian J Pathol Microbiol 2015;58:133-133

How to cite this URL:
Aravindan K P. Color Atlas of Tissue Response to Biomaterials. Indian J Pathol Microbiol [serial online] 2015 [cited 2021 Apr 16 ];58:133-133
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Full Text


Authors: Mira Mohanty, A. Sabareeswaran, Sulekha Baby, Joseph Sebastian, Caroline S. Diana

Edited by: Mira Mohanty

Edition: First edition

Publisher: Jaypee Brothers Medical Publishers; New Delhi

Pages: 202

It falls to the pathologist's lot to see strange things under the microscope. After >30 years in pathology, you begin to feel you have seen them all, but apparently surprises are never exhausted. There was, for instance, the case of a necrosed uterus after C-section that I saw recently, in which was present a foreign material. It was a kind of polyglactin suture material, but the important question was whether the tissue necrosis was due to the material or not. Then, there was the case of a thrombosed vessel in which a strange looking material could be seen. On further enquiry, there was a history of vascular graft surgery. There was intense giant cell reaction around what was a polytetrafluoroethylene graft. A few of such recent cases made me realize the importance of recognizing extraneous medical material and the body's reaction to them in routine histopathology material. Textbooks and even the net offers little in a way of help when you frantically search before giving a report. In short, there is an acute need for a book that helps you with the histopathology of medical material in tissues.

"Color Atlas of Tissue Reaction to Biomaterials" authored by Mohanty et al. is a very timely book that fulfills the need mentioned above. [1] The team of authors headed by a Pathologist has long years of experience in India's premier research institution for developing and testing biomaterials. The book is a delight for its aesthetics of production and also for the quality of photographs. It is divided into six sections. The first is a write-up that deals with the preparation of tissues with implants for microscopy, which includes methods like resin embedding for hard tissues. The second and third parts illustrate various tissue reactions to implants in soft tissue and bone respectively. The reaction in bone especially may not be familiar to many. The fourth section deals with the preclinical evaluation of biomaterials and medical devices, which include artificial valves, scaffolding material in bone, dental filling, vascular grafts, etc. The testing is done in different animal models with elective necropsy at various time periods for gross and microscopic evaluation. The fifth section illustrates retrieved clinical implants. Many implants may become nonfunctional over a long period of time, and some may have to be removed for adverse effects it has produced on adjacent tissues. Now that nearly two decades or so have passed since clinical implants came to into wide use, the number of explants being given to pathologists for evaluation is also bound to increase and we are likely to see many more in future. These illustrations would be of great help not merely for recognizing the pathological changes produced, but also for recognizing the nature of the explant material as well. The final short chapter is on artifacts that may be encountered along with such material, which should not be mistaken for implants or tissue reaction to it.

This lavishly illustrated book is a must for any pathology library. It will be indispensible for the reporting histopathologists and oral pathologists. Another group that will be greatly benefited by it are those engaged in evaluation of implant materials.

Flaws? No major one that I could spot. I wish that the legends would be slightly more descriptive in the next edition.


1Mohanty M, Sabareeswaran A, Baby S, Sebastian J, Diana CS. Color Atlas of Tissue Reaction to Biomaterials. New Delhi: Jaypee Brothers Medical Publishers; 2014.