Indian Journal of Pathology and Microbiology

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 58  |  Issue : 1  |  Page : 7--11

Warthin俟Q製 tumor: An unknown pathogenesis: A neoplasm or a reactive hyperplasia?


Arpaci Bozdogan Rabia1, Linke Serınsoz Ebru1, Kara Tuba1, Gursoy Didar1, Orekici Gulhan2, Ozcan Cengiz3 
1 Department of Pathology, Mersin University Medical School, Mersin, Turkey
2 Department of Biostatistics, Mersin University Medical School, Mersin, Turkey
3 Department of Otorhinolaryngology, Mersin University Medical School, Mersin, Turkey

Correspondence Address:
Dr. Arpaci Bozdogan Rabia
Department of Pathology, Mersin University Medical School, Mersin
Turkey

Background and Aims: To examine the probable role of angiogenesis and lymphangiogenesis in the pathogenesis of Warthin俟Q製 tumor. Materials and Methods: Sixty-one patients with Warthin俟Q製 tumor (n = 40), branchial cysts (n = 6), thymic cysts (n = 3), or tonsillar lymphoepithelial cysts (n = 12) were included. Forty Warthin俟Q製 tumors were used as the lesion group, and 21 lymphoepithelial cysts were used as a control group. 29 lymph nodes around the Warthin俟Q製 tumor, four of which showed salivary duct inclusions, were also evaluated. Blood vessel density was defined as an indicator of angiogenesis by examining CD31 and FVIII Ag expression, and lymphatic vascular density was defined as an indicator of lymphangiogenesis by evaluating LYVE-1 and podoplanin expression by immunohistochemical analysis. Statistical Analysis Used: Data are expressed with descriptive statistics. Comparative analysis was performed using Shapiro-Wilks, Mann-Whitney U, and Kruskal-Wallis tests. A P < 0.005 was considered to indicate statistical significance. Statistical analysis was performed using the MedCalc ® v.10.3.0 software. Results: The lesion group had higher mean values of age (58 vs. 11 years, P = 0.001), smoking rate (92.3% vs. 19%, P < 0.001), stromal degeneration (100% vs. 42.9%, P < 0.001), lymph node involvement around the lesion (87.9% vs. 12.1%, P < 0.001), salivary duct inclusion (25% vs. 0%, P = 0.0001), than those of lymphoepithelial cysts. Blood vessel density (51.92 ± 25.64 vs. 8 ± 5.35, number/5 high power fields (HPF), P < 0.001) and lymphatic vascular density (68.95 ± 21.32 vs. 21.10 ± 4.05 number/5 HPF, P < 0.001) were higher in Warthin俟Q製 tumors than lymphoepithelial cysts. Warthin俟Q製 tumors, and lymph nodes with inclusions had similar levels of blood and lymphatic vascular density, which was higher than those of lymph nodes (P < 0.0001). Conclusions: Warthin俟Q製 tumor is a true neoplastic epithelial proliferation associated with increased angiogenesis and lymphangiogenesis and induces reactive lymph node hyperplasia.


How to cite this article:
Rabia AB, Ebru LS, Tuba K, Didar G, Gulhan O, Cengiz O. Warthin's tumor: An unknown pathogenesis: A neoplasm or a reactive hyperplasia?.Indian J Pathol Microbiol 2015;58:7-11


How to cite this URL:
Rabia AB, Ebru LS, Tuba K, Didar G, Gulhan O, Cengiz O. Warthin's tumor: An unknown pathogenesis: A neoplasm or a reactive hyperplasia?. Indian J Pathol Microbiol [serial online] 2015 [cited 2021 Apr 19 ];58:7-11
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2015;volume=58;issue=1;spage=7;epage=11;aulast=Rabia;type=0