Indian Journal of Pathology and Microbiology

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 62  |  Issue : 4  |  Page : 544--548

Risk of malignancy in Thyroid “Atypia of undetermined significance/Follicular lesion of undetermined significance” and its subcategories – A 5-year experience


Abha Thakur1, Haimanti Sarin1, Dilpreet Kaur1, Deepak Sarin2 
1 Department of Pathology, Medanta-The Medicity Hospital, Gurgaon, India
2 Department of Head and Neck Oncology, Medanta-The Medicity Hospital, Gurgaon, India

Correspondence Address:
Abha Thakur
Department of Pathology, Medanta-The Medicity Hospital, Gurgaon
India

Context: Atypia of undetermined significance/Follicular lesion of undetermined significance [AUS/FLUS] is a heterogeneous category with a wide range of risk of malignancy [ROM] reported in the literature. The Bethesda system for reporting thyroid cytopathology [TBSRTC], 2017 has recommended subcategorization of AUS/FLUS. Aims: To evaluate the ROM in thyroid nodules categorized as AUS/FLUS, as well as separate ROM for each of the five subcategories. Settings and Design: Retrospective analytic study. Methods and Materials: A retrospective audit was conducted for all thyroid fine-needle aspiration cytology (FNAC) from January 2013 to December 2017. Slides for cases with follow-up histopathology were reviewed, classified into the five recommended subcategories, and differential ROM was calculated. Statistical Analysis Used: z test for comparison of proportions was done to evaluate the difference in ROM among different subcategories of AUS/FLUS. The P value of less than 0.05 was taken as statistically significant. Results: Total number of thyroid FNACs reported was 1,630, of which 122 were AUS/FLUS (7.5%). Histopathology was available in 49 cases, out of which 18 were malignant (ROM = 36.7%). The risk of malignancy (ROM) for nodules with architectural and cytologic atypia was higher (43.8%) than ROM for nodules with only architectural atypia (16.7%). Conclusions: The sub-classification of AUS/FLUS into subcategories as recommended by TBSRTC, 2017 may better stratify the malignancy risk and guide future management guidelines.


How to cite this article:
Thakur A, Sarin H, Kaur D, Sarin D. Risk of malignancy in Thyroid “Atypia of undetermined significance/Follicular lesion of undetermined significance” and its subcategories – A 5-year experience.Indian J Pathol Microbiol 2019;62:544-548


How to cite this URL:
Thakur A, Sarin H, Kaur D, Sarin D. Risk of malignancy in Thyroid “Atypia of undetermined significance/Follicular lesion of undetermined significance” and its subcategories – A 5-year experience. Indian J Pathol Microbiol [serial online] 2019 [cited 2021 Jun 16 ];62:544-548
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=4;spage=544;epage=548;aulast=Thakur;type=0