Indian Journal of Pathology and Microbiology

EDITORIAL
Year
: 2020  |  Volume : 63  |  Issue : 4  |  Page : 513--514

From Editor's desk


Ranjan Agrawal 
 MD; FIC Path; MIAC, DHA, Professor, Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India

Correspondence Address:
Ranjan Agrawal
MD; FIC Path; MIAC, DHA, Professor, Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh
India




How to cite this article:
Agrawal R. From Editor's desk.Indian J Pathol Microbiol 2020;63:513-514


How to cite this URL:
Agrawal R. From Editor's desk. Indian J Pathol Microbiol [serial online] 2020 [cited 2020 Nov 25 ];63:513-514
Available from: https://www.ijpmonline.org/text.asp?2020/63/4/513/299296


Full Text



Dear Readers,

The pandemic has been spreading fast and far. In spite of all odds and circumstances, all the four issues of IJPM for the current year have been published online as well as in print forms. Many of those involved in the publishing were affected by the disease but stood to the commitment. IJPM always has a rich blend of articles in different fields of Pathology. The October–December 2020 issue also includes research publications of manuscripts dealing with the entire spectrum, including the malignant as well as the benign pathologies that hold great significance for the readers.

Cases of oral squamous cell carcinoma are on the rise, maybe due to lifestyle changes or could be a result of early diagnosis. In this issue of IJPM, we have articles related to oral malignancies, further depicting the rising trend of this particular malignancy. Treatment of oral malignancies is highly variable. Complete surgical resection and adjuvant therapy both may be required depending on the stage, depth, and status of surgical margin. A study by Parekh et al. emphasized on the characteristics of tumor–tissue interface of worst pattern of invasion, size of tumor cell nest, tumor budding, and lymphocytic host response. These parameters whenever included in the report serve as important prognostic markers.[1] Use of apoptotic index in the study by Pawar et al. was carried out to assess the proliferative index, especially in areas showing dysplasia of the oral epithelium. Further, different grades of dysplasia could be estimated by using this index, further helping to initiate the targeted therapy.[2] Cisplatin is a drug of choice used in patients with squamous cell carcinoma of the oral cavity. The principle on which this drug acts is based on the DNA repair gene in the carcinogenesis pathway. Identification of the genotypes that pose great risk and susceptibility to oral squamous cell carcinoma may thus be identified.[3]

Mucin (MUC) expression in invasive carcinoma breast nowadays holds great promise in diagnosis as well as the prognosis. Immunohistochemical markers are used to identify the normal areas, in situ as well as the invasive areas. Overexpression of MUCs was more in malignant lesions as compared to the normal areas. MUC1 overexpression has been associated with a poor prognosis, while MUC6 expression has been associated with lymphovascular invasion. A study by Oral et al. serves as a helpful guide against specific therapeutic target in patients with carcinoma breast.[4] Neuroendocrine carcinomas of the breast constitute less number of cases but have now started to make their impact. A series by Singh et al. emphasized on the need for evaluating these cases since they have higher metastatic potential and the patients are benefitted using endocrine therapy as compared to the ductal carcinomas. The authors even suggested use of antiangiogenic markers in these tumors.[5] Original study by Singla et al. on carcinoma breast highlights the role of increased platelet aggregation in metastatic cases as well as higher histological grades of malignancy. Large platelet aggregates may disseminate the neoplastic cells in microcirculation and also aid in their extravasation at the metastatic sites as suggested by the authors.[6]

A study by Tang et al. adds to the list of quality articles included in this issue. Expression of Inc RNA SNHG 1 in carcinoma prostate may serve as an important prognostic biomarker as well as potential therapeutic target for the treatment of this malignancy.[7] Aorto-esophageal fistulas are fatal if not diagnosed early but are often misdiagnosed or even missed until detected on autopsy. Timely management of this malformation may help in saving many lives. Vaideeswar in his article has extensively studied cases over a span of 20 years, with a total of 10 cases included in their publication.[8] Besides these original and research articles, there are case reports, images, and letter to the editor that would attract wide readership. They are rare reports and pave further path for future researches.

I request all our esteemed readers to continue to contribute their manuscripts to IJPM. Rising impact factor of IJPM as well as relaxed work schedule of many led to a major inflow of articles this year. The entire editorial team as well as the reviewers has worked very hard to take care of them in a very timely manner. There were no holding back of the articles at any step. I especially thank all the reviewers who spared their valuable time in going thoroughly through the manuscripts and reviewing them even multiple times till they turned out into quality publications we value your contribution. Few reviewers have reviewed more than hundred articles for IJPM as well. I extend a deep gratitude to them and sending them appreciation certificates.

References

1Parekh D, Kukreja P, Mallick I, Roy P. Worst pattern of invasion-type 4 (WPOI-4) and Lymphocyte host response should be mandatory reporting criteria for oral cavity squamous cell carcinoma: A re-look at the American Joint Committee of Cancer (AJCC) minimum dataset. Indian J Pathol Microbiol 2020;63:527-33.
2Pawar RB, Palaskar SJ, Kalavankar SS. Assessment of apoptotic index in various grades of oral epithelial dysplasia: A cross-sectional study. Indian J Pathol Microbiol 2020;63:534-7.
3Avinash Tejasvi ML, Maragathavalli G, Putcha UK, Krishna RM, Vijayaraghavan R, Anuekha AC. Impact of ERCC1 Gene polymorphisms on response to cisplatin based therapy in oral squamous cell carcinoma (OSCC) patients. Indian J Pathol Microbiol 2020;63:538-43.
4Oral O, Unverdi H, Kumcu E, Turkbey D, Dogan S, Hucumenoglu S. Associations between the expression of mucins (MUC1, MUC2, MUC5AC, and MUC6) and clinicopathologic parameters of human breast carcinomas. Indian J Pathol Microbiol 2020;63:551-8.
5Singh V, Kaur N, Mandal S, Mallya V, Tomar R, Khurana N, et al. Neuroendocrine carcinomas of the breast: Case series with review of literature. Indian J Pathol Microbiol 2020;63:559-63.
6Singla T, Singla G, Ranga S, Singla S, Arora R. Role of platelet aggregation in metastatic breast cancer patients. Indian J Pathol Microbiol 2020;63:564-9.
7Tang Q, Li Z, Han W, Cheng S, Wang Y. High expression of lncRNA SNHG1 in prostate cancer patients and inhibition of SNHG1 suppresses cell proliferation and promotes apoptosis. Indian J Pathol Microbiol 2020;63:575-80.
8Vaideeswar P. Aorto-esophageal fistula – An autopsy series. Indian J Pathol Microbiol 2020;63:597-9.