Indian Journal of Pathology and Microbiology

: 2022  |  Volume : 65  |  Issue : 3  |  Page : 519--520

From Editor's desk

Ranjan Agrawal 
 MD; FIC Path; MAMS; MIAC; DHA, Professor & Head, Department ofPathology, Rajshree Medical Research Institute, Bareilly, Uttar Pradesh, India

Correspondence Address:
Ranjan Agrawal
MD; FIC Path; MAMS; MIAC; DHA, Professor & Head, Department of Pathology, Rajshree Medical Research Institute, Bareilly, Uttar Pradesh

How to cite this article:
Agrawal R. From Editor's desk.Indian J Pathol Microbiol 2022;65:519-520

How to cite this URL:
Agrawal R. From Editor's desk. Indian J Pathol Microbiol [serial online] 2022 [cited 2022 Oct 3 ];65:519-520
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Dear Readers,

Good day to all. At the outset, I would like to share my gratitude to all the authors, reviewers, and members of the editorial board because of whom IJPM has risen to its present status. In the recently declared Journal Citation Report 2022, the IJPM impact factor for 2021 has been 0.773, which is an increase from the existing 0.740. The rise may be slow but is steady, as noticed during the last 4 years of my tenure.

The July–September 2022 issue of IJPM has a saga of articles ranging from morphology to novel immunohistochemical markers as well as molecular diagnostics. These articles hold great value in the enhancement of academic development of the journal.

Microvessel density has a prognostic role in cancer diagnosis and treatment. Article by Harmankaya et al.[1] stated that VEGF expression, microvessel density, and the presence of perineural invasion did not carry any significance in the prognosis of local control of laryngeal squamous cell carcinoma, whereas VEGF expression was associated with the overall survival in these patients. Another study by Tian et al.[2] studied the association of microvessel density with CD 223, i.

e., lymphocyte activation gene-3 in cases of primary hepatocellular carcinoma. They concluded that high expression of CD 223 correlated with poor prognosis and increased angiogenesis. The author thus emphasized on CD 223 becoming a novel marker of primary hepatocellular carcinoma in terms of diagnosis or prognosis and even therapeutic aspects.

Gastrointestinal lesions are rampant in India probably secondary to multiple factors, including diet, Helicobacter pylori, etc. Publication by Sharma et al.[3] reported an increase in the number as well as severity of gastritis, mucosal nodularity, mucosal atrophy, and neoplasia when compared with those from North India. The authors then checked for the genotype of H. pylori that would be associated with increased virulence. The overall conclusion in the study was that the differences in the virulence genotype was not different in gastric biopsies from different regions, and therefore, the possibilities of severity in the clinical manifestations could be because of different genotypes in the host, genetic diversity of the infecting H. pylori, or else the local host factors. Liu et al.[4] studied the role of long intergenic non-protein coding RNA, regulator of reprogramming (LINC-ROR) in gastric cancer and reported that this regulator activates the epithelial–mesenchymal transition and may predict metastasis in patients with carcinoma stomach.

Inflammatory bowel diseases because of their similar findings may at times be missed out for an accurate diagnosis. β-Catenin and Rb proteins as immunohistochemical markers along with serum assays of ASCA and Þ-ANCA have been postulated as a good adjunct to morphology in the exact typing of inflammatory bowel diseases.[5]

Neonatal cholestasis because of biliary atresia or idiopathic neonatal hepatitis forms an important medical condition during the neonatal phase. There may be no major microscopic distinction among these entities nor there may be any significant liver damage, however, electron microscopy revealed intra-cellular damage, thus holding diagnostic value in such cases.[6]

I am very sure that these highly acclaimed articles would be of great benefit for all the readers. I further request all the authors to consider IJPM as their first performance journal.

Jai Hind !


1Harmankaya I, Yürüt-Çaloğlu V, Usta U, Türkkann G, Taştekin E, Çaloğlu M, et al. Prognostic importance of microvessel density, VEGF expression and perineural invasion in laryngeal cancer treated with adjuvant radiotherapy. Indian J Pathol Microbiol 2022;65:521-6.
2Tian J, Liu Y, Zhang TL, Xiao YN, Guo CY, Xie YH, et al. Clinical significance of LAG-3 on microvessel density in primary hepatocellular carcinoma. Indian J Pathol Microbiol 2022;65:581-8.
3Sharma N, Das P, Das R, Mahant S, Kalaivani M, Yadav R, et al. Correlation of Helicobacter pylori virulencegenotype & severity of mucosal inflammation ingastric biopsies from two geographically diverseregions in India. Indian J Pathol Microbiol 2022;65:535-44.
4Liu M, Zhang M, Yin H. Linc-ROR promotes invasion andmetastasis of gastric cancer by activating epithelial-mesenchymal transition. Indian J Pathol Microbiol 2022;65:545-50.
5Paridhi, Singh K, Kumar V, Tewari S, Misra V, Misra SP, et al. Role of Immunohistochemistry and serology in subclassifying the inflammatory bowel disease cases diagnosed as inflammatory bowel diseases ---unclassified on colonic biopsies. Indian J Pathol Microbiol 2022;65:558-64.
6Gürünlüoğlu S, Gül M, Zararsız G, Akpinar N, Varol FI, Demircan M, et al. Ultra-structural and histopathological features of liver biopsy taken during laparotomy to confirm the diagnosis of biliary atresia. Indian J Pathol Microbiol 2022;65:572-80.