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   2012| October-December  | Volume 55 | Issue 4  
    Online since March 4, 2013

 
 
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LETTERS TO EDITOR
Granulicatella adiacens - An unusual causative agent for carbuncle
Bichitrananda Swain, Sarita Otta
October-December 2012, 55(4):609-610
DOI:10.4103/0377-4929.107859  PMID:23455831
  14,121 82 2
CASE REPORTS
A 60-year-old lady with leonine facies: A rare diagnosis
Deepti Mutreja, Abhishek Purohit, Pawan K Singh, HP Pati
October-December 2012, 55(4):566-568
DOI:10.4103/0377-4929.107824  PMID:23455809
Systemic mastocytosis is a rare clonal disorder characterized by mast cell infiltration of one or more organs, with or without skin involvement. Leonine facies is a rare presentation and corresponds to the morphologic manifestation of diffuse dermal infiltration of the face as a result of long standing disease. Bone marrow aspiration and biopsy findings in a 60-year-old woman, who had extensive cutaneous infiltration due to systemic mastocytosis, resulting in 'leonine facies,' are described, and causes of leonine facies are discussed.
  12,975 140 1
LETTERS TO EDITOR
Multiple vessels in the umbilical cord: A report of four cases
Neha Singh, Seema Rao, Parul Sobti, Nita Khurana
October-December 2012, 55(4):597-598
DOI:10.4103/0377-4929.107846  PMID:23455823
  9,057 96 -
ORIGINAL ARTICLES
Micronucleus assay of buccal mucosa cells in smokers with the history of smoking less and more than 10 years
Noushin Jalayer Naderi, Sareh Farhadi, Samaneh Sarshar
October-December 2012, 55(4):433-438
DOI:10.4103/0377-4929.107774  PMID:23455775
Introduction and Aim: Cigarette smoking causes severe health problems such as cancer. Micronuclei are structures that present after genomic damages to the cells. The present study is aimed at evaluating the micronucleus assay of buccal mucosa cells in smokers who smoked less or more than 10 years. Materials and Methods: The present study has been a historical cohort study. The smokers were divided into two groups: First group include individuals with a smoking history less than 10 years (14 samples) and second group with the smoking history of more than 10 years (26 samples).The control group consisted of nonsmokers (23 samples). The exfoliated buccal mucosa cells were scrapped using spatula and were spread over the glass slide. Feulgen method was used for micronucleus staining. 500 cells per subjects were counted. The presence of micronucleus in all subjects and the mean percentage of micronucleus in nuclei were determined. Data were subjected to statistical analysis using T-test. Results: The mean number of micronucleus of buccal mucosa cells in nonsmokers, first group (smoking history less than 10 years) and second group (smoking history more than 10 years) was 0.94 ± 0.94, 1.89 ± 0.62 and 2.01 ± 0.93 respectively. The difference was statistically significant (P < 0.002). Considering the number of micronuclei of the buccal mucosa cells, the difference between groups 1 and 2 was not significant (P < 0.6). The mean percentage of micronucleated cells in nonsmokers, group 1 and group 2 was 2.26 ± 2.17%, 13.9 ± 5.90 and14.3 ± 7.97, respectively. The difference was statistically significant (P < 0.001).The difference between the percentage of the cells with micronucleus in smokers with a smoking history of less or more than 10 years was not significant (P < 0.6). Conclusion: The mean number of micronuclei in buccal mucosa cells of the nonsmokers was significantly lower than that of the smokers. However, the mean number of micronucleus of buccal mucosa cells in smokers who smoked more than 10 years was higher than smokers who smoked less than 10 years. Increasing the smoking duration could heighten the frequency of micronucleus; however, the difference was not significant.
  8,422 699 11
BRIEF COMMUNICATIONS
Tumefactive demyelinating lesions: A Clinicopathological correlative study
R Neelima, K Krishnakumar, MD Nair, C Kesavadas, Divyata Rajendra Hingwala, VV Radhakrishnan, Sruthi S Nair
October-December 2012, 55(4):496-500
DOI:10.4103/0377-4929.107788  PMID:23455787
Tumefactive demyelinating (TDL) lesions are focal zones of demyelination in the central nervous system and they often mimic the neuroimaging features of an intraxial neoplasm. In this report we describe the clinical, neuroimaging and neuropathological features of six cases of TDL. Only in two patients the neuroimaging features in MRI (magnetic resonance imaging) scans were suggestive of TDL while in the other four cases a diagnosis of glioma was suggested. In order to establish a confirmatory diagnosis neuronavigation/stereotactic biopsy was undertaken and the diagnosis of TDL was established in all six cases at histopathology. Two out of six patients did not respond to the conventional corticosteroid therapy and they were treated with plasma exchange. It is being concluded that neuronavigation biopsy, though provide only a small amount of tissue, and is extremely useful in making the diagnosis of TDL.
  8,458 289 4
CASE REPORTS
Low grade follicular lymphoma with high proliferation index; diagnostic and management issues
Sreeya Das, Debdatta Basu, Biswajit Dubashi, Ankit Jain
October-December 2012, 55(4):516-518
DOI:10.4103/0377-4929.107795  PMID:23455792
Follicular Lymphoma (FL) is the second most common B-Non Hodgkin Lymphoma after diffuse large B cell lymphoma (DLBCL). Low grade FL is known for its indolent behavior; however, one subset of FL behave aggressively and may require intensive therapy. One of the diagnostic issues in FL is to identify this subgroup of cases. Proliferation index can have prognostic importance in this subset of cases. We discuss one case of low grade FL with a paradoxically high proliferative index. A 63 year male presented with generalized lymphadenopathy of one year duration, which was gradually increasing in size. On examination, patient had bilateral cervical, axillary and inguinal nodes. Biopsy of the left cervical lymph node was reported as FL - Grade 2, with high proliferative Index (60%). The patient was put on CHOP regimen targeted for high grade lymphomas, and had complete remission. High proliferative index in FL is a poor prognostic factor irrespective of the histologic grade. So, proliferative index should be assessed in all cases of FL as an adjunct to histologic grading.
  8,413 127 -
ORIGINAL ARTICLES
Usefulness of automated cell counter in detection of malaria in a cancer set up-Our experience
Monica Jain, Surbhi Gupta, Jyotika Jain, Rajesh Kumar Grover
October-December 2012, 55(4):467-473
DOI:10.4103/0377-4929.107782  PMID:23455781
Background: Malaria diagnosis presents a challenge to all laboratories. In malaria-endemic areas, there is a need for rapid, sensitive and cost-effective method to effectively screen all samples, especially when the workload is very high. Various hematology analyzers have been investigated for detection of malaria in the past. Here, we present our experience of malaria detection in a cancer hospital where a large number of complete blood count requests are received either before or during chemotherapy. Fever, being a very common symptom in cancer patients, causes a suspicion of malaria. Aim: This study was conducted to assess the usefulness of hematology cell counter, viz. WBC-DIFF and WBC/BASO scatter plots and the flaggings generated in malaria-positive cases. The occurrence of pseudoeosinophilia as reported by previous studies was also assessed. The parasitic index was determined and its correlation with the abnormalities found on the Hematology analyzer was also studied. Materials and Methods: Blood samples were collected from 80 out-patient department and inpatients with various solid as well as hematological malignancies, who presented with acute febrile illness during September 2010 and January 2012, and for whom complete blood cell analysis and peripheral smear for malaria parasite had been requested. Results: Of the 80 patients who presented with fever and suspicion of malaria, 29 patients were positive for malaria and 10 cases were diagnosed incidentally by the findings on the cell counter and were confirmed by Giemsa-stained blood smears. The sensitivity and specificity of the abnormalities detected in the WBC-Diff channel in detecting malaria is 82% and 100% respectively. Using WBC-BASO channel abnormality for initial diagnosis the sensitivity and specificity is 50% and 92.5% respectively. The sensitivity and specificity with respect to pseudoeosinophilia is 18% and 100% respectively. The most common WBC and PLT flags were leukopenia, atypical lymphocytes, lymphopenia, WBC abnormal scattergram, platelet clumps, thrombocytopenia, platelet abnormal distribution flag. Conclusion: The instrument provides significantly valuable diagnostic parameters in detecting acute Plasmodium vivax malaria; however, it is not very useful for acute falciparum malaria infection. It is suggested that the laboratories using the hematology analyzers should be aware of such specific parameters, even in the absence of a clinical request.
  7,653 634 3
LETTERS TO EDITOR
Icteric donor plasma: To transfuse or to discard?
Kusum D Jashnani, Ashvini Karwande, Gururaj Puranik
October-December 2012, 55(4):604-605
DOI:10.4103/0377-4929.107853  PMID:23455827
  8,013 104 1
CASE REPORTS
An unusual case of invasive papillary carcinoma of the breast
Aysen Terzi, Aysegul Hasegeli Uner
October-December 2012, 55(4):543-545
DOI:10.4103/0377-4929.107809  PMID:23455801
Invasive papillary carcinoma is a rare variant of breast cancer. We report an unusual case of invasive papillary carcinoma of the breast with high nuclear grade, brisk mitosis, necrosis, extensive apocrine differentiation, and intense lymphoplasmacytic infiltrate; additionally triple-negativity for estrogen and progesterone receptors and Her2 neu. The patient underwent modified radical mastectomy and adjuvant chemotherapy. But, it was a node negative breast carcinoma. Increasing the awareness of this clinicopathologic entity would be helpful in avoiding overtreatment of patients with this cancer even if the tumor has negative morphological and immunohistochemical prognosticators.
  7,185 165 1
ORIGINAL ARTICLES
Spectrum of adrenal lesions on fine needle aspiration cytology
Chanchal Rana, Narendra Krishnani, Niraj Kumari
October-December 2012, 55(4):461-466
DOI:10.4103/0377-4929.107781  PMID:23455780
Background: Fine needle aspiration (FNA) cytology of adrenal gland is not a commonly performed technique and is limited primarily to tertiary care centers. However, it is a sensitive and specific procedure in the workup of patients with adrenal gland's mass lesions. Though cytomorphological features for various lesions have been described, there are a limited number of studies in cytologic literature. Aims: We report our 7 years of experience in FNAC of adrenal lesions. We have not only described the cytomorphological details of different lesions, but also tried to discuss the various diagnostic difficulties encountered during reporting of adrenal fine needle aspirations. Materials and Methods: All ultrasound-guided percutaneous aspirations of adrenal gland received in the department between the years 2002 and 2009 were reviewed. There were a total of 52 FNA samples of adrenal masses from 35 patients in 7 years. The lesions were categorized as non-neoplastic and neoplastic categories. Neoplastic lesions were further divided into benign and malignant lesions. Results: In our study, FNA proved to be 100% specific for diagnosing malignant lesions. The overall inadequacy rate was 11.4% with no major complications of the procedure. A wide variety of non-neoplastic as well as neoplastic lesions were identified.
  6,719 413 3
CASE REPORTS
Vulvar basal cell carcinoma
Mustafa Kara, E Colgecen, Erdogan Nilsen Yildirim
October-December 2012, 55(4):583-584
DOI:10.4103/0377-4929.107835  PMID:23455815
Although the basal cell carcinoma (BCC) is the most common malignancy of skin, it is rarely seen in vulva and constitutes 2% to 4% of all vulvar cancers. The cause is unknown but, chronic vulvar irritation is the most important underlying factor. The patients over 60 years are affected more frequently than younger ones.
  7,010 89 5
BRIEF COMMUNICATIONS
Cri du chat syndrome: A series of five cases
Harsha M Dangare, Samuel P Oommen, Amisha N Sheth, Beena Koshy, Reeba Roshan, Maya M Thomas, Sumita Danda, Vivi M Srivastava
October-December 2012, 55(4):501-505
DOI:10.4103/0377-4929.107791  PMID:23455788
The cri du chat syndrome (CdCS) is a chromosomal deletion syndrome associated with a partial deletion of the short (p) arm of chromosome 5. We describe five children who were diagnosed to have CdCS by conventional cytogenetic analysis. The deletion was at 5p15 in four patients, whereas the fifth had a larger, more proximal deletion at 5p14. Fluorescence in situ hybridization (FISH) analysis confirmed the deletion of the CdCS critical region at 5p15.2. All five children had global developmental delay and dysmorphism with microcephaly. The other clinical features were variable. Since the clinical diagnosis of CdCS may not always be evident because of the phenotypic heterogeneity, cytogenetic analysis is necessary to establish the diagnosis and confirm that the deletion involves the CdCS critical region. This will enable early intervention which plays an important role in improving the outcome.
  6,599 145 1
ORIGINAL ARTICLES
Peripheral T-cell lymphoma: Frequency and distribution in a tertiary referral center in South India
Deepak K Burad, Manipadam M Therese, Sheila Nair
October-December 2012, 55(4):429-432
DOI:10.4103/0377-4929.107770  PMID:23455774
Background and Aim: Peripheral T/NK-cell lymphomas are uncommon types of non-Hodgkin's lymphoma (NHL) with a higher frequency in Far East countries as compared to the West. This study was undertaken to ascertain the frequency and distribution pattern of peripheral T-cell lymphomas (PTCLs) diagnosed in a tertiary care center in South India. Materials and Methods: This retrospective study was carried out in Department of General Pathology, Christian Medical College, Vellore. The time period was for 2 years from 1 st January 2008 till 31st December 2009. All PTCLs were reviewed and classified according to the World Health Organization (WHO) 2008 classification. Results: Of a total of 1032 cases of NHL, 180 cases were PTCL, which accounted for 17.4% cases of all the NHLs. Of these, PTCL, not otherwise specified (PTCL, NOS) was the most common subtype (48 cases, 26.1%), followed by anaplastic large cell lymphoma (41 cases, 22.8%), mycosis fungoides (21 cases, 11.7%), angioimmunoblastic T-cell lymphoma (16 cases, 8.9%), subcutaneous panniculitis like T-cell lymphoma (15 cases, 8.4%), extranodal NK/T-cell lymphoma, nasal type (12 cases, 6.7%), and hepatosplenic T-cell lymphoma (10 cases, 5.6%). The most common primary site of presentation was nodal accounting for 42% followed by cutaneous (34%), upper aerodigestive sites (8.9%), spleen (6.7%), and gastrointestinal tract (GIT; 3.3%). Conclusions: This is the largest single study on PTCLs in India and we document that its frequency is higher than that reported in Western literature and previous Indian studies and almost similar to that reported in some Far East studies. The frequency of mycosis fungoides, subcutaneous panniculitis like T-cell lymphoma, and hepatosplenic T-cell lymphoma was higher than that reported in the World literature and previous Indian studies. The frequency of extranodal NK/T-cell lymphoma and angioimmunoblastic T-cell lymphoma was much lower than that reported in the Far East literature.
  5,561 524 3
CASE REPORTS
Histological identification of muscular sarcocystis: A report of two cases
Mani Makhija
October-December 2012, 55(4):552-554
DOI:10.4103/0377-4929.107813  PMID:23455804
Sarcocystis is an apicomplexan protozoan belonging to same phylum as toxoplasma. The parasite encysts inside striated muscles of its intermediate host. Humans are accidental host infected by eating food or water contaminated with oocysts or sporocysts of an infected definitive host. The infection is increasing in Southeast Asia and may be overlooked in histological sections if one is not aware of the histomorphological features. The size and shape of the bradyzoites and the appearance of the cyst wall are the reliable features to distinguish this parasite from other parasites of the same phylum. The incidence of human infection is rising in Southeast Asia and histopathology is an important method for the diagnosis of muscular infection. It is important to recognize the histomorphology of this parasite and its differentiation from similar parasites.
  5,839 99 3
ORIGINAL ARTICLES
Epithelial mesenchymal transition in urothelial carcinoma: Twist in the tale
Purnima Paliwal, Disha Arora, Ashwani K Mishra
October-December 2012, 55(4):443-449
DOI:10.4103/0377-4929.107777  PMID:23455777
Context: Epithelial to mesenchymal transition (EMT) is a process involving conversion of cells from an epithelial to mesenchymal phenotype. The role of candidate genes promoting EMT and favoring a promigratory phenotype has been demonstrated in epithelial cancer. Existing scientific research has not yielded a clinically relevant biomarker with predictive capacity beyond grade and stage in bladder cancer. Aim: The purpose of this study is to evaluate the immunohistochemical expression pattern of a panel of epithelial and mesenchymal markers in paraffin-embedded archival material of primary urothelial carcinoma as evidence of EMT. Materials and Methods: Immunohistochemical expression of transcription factor twist, epithelial (E-cadherin, cytokeratin) and mesenchymal (vimentin, N-cadherin) markers was analyzed on archival paraffin-embedded tissue samples from 48 patients with diagnosis of primary urothelial carcinoma of bladder. Statistical Analysis: Karl Pearson's χ2 test was used to evaluate the association between the expression of immunohistochemical markers and various clinico-pathologic variables. Non-parametric Kendall's tau-b statistics was used to determine the correlation between categorical variables. Results and Conclusion: The study demonstrated statistically significant association of cytokeratin, E-cadherin, vimentin, and twist with stage and grade of bladder cancer. Since these markers form part of the spectrum of changes associated with EMT, the study establishes proof of concept of the existence of this process in vivo. A significant negative correlation was noted between the expression of twist and E-cadherin. Exploiting its role as a transcriptional repressor of E-cadherin, twist may prove to be a useful candidate for targeted therapy in urologic oncology.
  5,549 238 10
LETTERS TO EDITOR
A rare but diagnostic fungal microorganism in cervical Pap smears
Gonca Ozgun, Baris A Borsa
October-December 2012, 55(4):606-607
DOI:10.4103/0377-4929.107854  PMID:23455828
  5,170 141 -
ORIGINAL ARTICLES
Significant increases in monocyte counts and serum creatine kinase in acute myocardial infarction versus general infections
Haseeb A Khan, Abdullah S Alhomida, Samia H Sobki, Abdulrahman Al Moghairi
October-December 2012, 55(4):474-477
DOI:10.4103/0377-4929.107783  PMID:23455782
Background: Biomarkers specificity is an important factor for their reliable utilization. Known markers for acute myocardial infarction (AMI), including creatine kinase (CK), C-reactive protein (CRP), and blood cell counts are thought to be altered in other pathologic conditions, such as infections. Aim: To compare the level of these biomarkers in AMI patients and infected controls with respect to normal subjects. Materials and Methods: We recruited 15 AMI patients, 15 patients with bacterial infections (infected control group) and 35 normal subjects. Peripheral blood samples were obtained for blood cell counts and biochemical analyses. Results: Only monocytes were significantly increased in AMI patients (0.793 × 10 9 /L) than normal controls (0.497 × 10 9 /L). Infected controls showed a significant increase in total white blood cell (11.50 × 10 9 /L versus 6.149 × 10 9 /L) and neutrophil (9.360 versus 3.223 × 10 9 /L) counts and a significant decrease in red blood cell (3.750 versus 5.105 × 10 12 /L) counts as compared with normal controls. Serum CK was significantly increased in AMI patients (313.20 ± 94.84 U/L) and decreased in infected controls (48.40 ± 10.35 U/L) as compared with normal controls (100.82 ± 8.86 U/L). The levels of CRP were significantly higher in infected controls (136.93 ± 34.83 mg/L) and nonsignificantly higher in AMI patients (38.53 ± 12.76 mg/L) than normal controls (3.48 ± 0.59 mg/L). Monocytes were significantly correlated with both CK and CRP; however, there was no correlation between CK and CRP. Conclusion: Differential trends of monocytes and CK in AMI and infective controls point toward their possible application in prognosis of AMI patients.
  4,967 157 3
Correlation between HER2 gene amplification and protein overexpression through fluorescence in situ hybridization and immunohistochemistry in breast carcinoma patients
RN Makroo, Mohit Chowdhry, Manoj Kumar, Priyanka Srivastava, Richa Tyagi, Preeti Bhadauria, Sumaid Kaul, Ramesh Sarin, PK Das, Harsh Dua
October-December 2012, 55(4):481-484
DOI:10.4103/0377-4929.107785  PMID:23455784
Background : In India, the incidence of breast cancer has increased in the urban population, with 1 in every 22 women diagnosed with breast cancer. It is important to know the HER2/neu gene status for a better prognostication of these patients. Aim : The aim of this study was to compare the efficacy of fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) for determining HER2/neu alteration in breast carcinoma. Materials and Methods : A total of 188 histologically proven breast carcinoma cases between the years 2007 and 2011 were retrospectively analyzed on the paraffin tissue sections by both IHC and FISH techniques. FISH for HER2/neu gene amplification was performed on cases where the IHC status was already known and the results were compared. Results : A total of 64 (30%) patients were found to be amplified and the remaining 124 (65.9%) cases were found to be unamplified through FISH. Patients observed with 3+ reading on IHC were later confirmed as unamplified in 29.5% cases through FISH. Conclusion : It has been confirmed with the present study that IHC is a prudent first-step technique to screen tissue samples for HER2/neu gene status, but should be supplemented with the FISH technique especially in equivocal cases.
  4,423 200 2
CASE REPORTS
CD34 positive-microgranular variant of acute promyelocytic leukemia in a child
Ashwini R Nargund, Geeta V Patil, CP Raghuram, Eswarachary Venkataswamy
October-December 2012, 55(4):574-577
DOI:10.4103/0377-4929.107828  PMID:23455812
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. APL is rare in children (approximately 10% of childhood AML) and is characterized by a higher incidence of hyperleukocytosis, an increased incidence of microgranular morphology, the presence of balanced t(15;17)(q22;q11.2-12) translocation, and more frequent occurrence of the PML-RARα isoforms bcr 2 and bcr 3 compared to adults. The cytomorphology of microgranular variant blasts is obviously different from AML M3 blasts; these cells have a nongranular or hypogranular cytoplasm or contain fine dust-like cytoplasmic azurophil granules that may not be apparent by light microscopy. This case report emphasizes the importance of a high index of suspicion for the diagnosis of APL, the hypogranular variant in particular. They are responsive to differentiation therapy with all trans-retinoic acid and complete remission in seen in >80% cases.
  4,503 104 -
LETTERS TO EDITOR
Multilocular epithelial cyst of spleen: A rare occurrence
Madakshira Gopal Manoj, Prathiba Misra, Sunita Kakkar
October-December 2012, 55(4):602-604
DOI:10.4103/0377-4929.107850  PMID:23455826
  4,403 70 3
CASE REPORTS
A fatal case of bone marrow embolism of unknown cause masquerading clinically as dengue shock syndrome
Subramanian Kalaivani Selvi, Rakhee Kar, Mehalingam Vadivelan, Dharanipragada Krishna Suri Subrahmanyam
October-December 2012, 55(4):572-573
DOI:10.4103/0377-4929.107827  PMID:23455811
Bone marrow fat embolism usually occurs following multiple bone fractures, intraosseous surgical procedures, following vigorous cardiac resuscitation, ecclampsia, sickle cell anemia, malignancies, etc. We present a case of 70-year-old male who presented with fever, cough with expectoration, respiratory distress, altered sensorium, hypotension and thrombocytopenia, and diagnosed to have dengue shock syndrome and expired within 1 day of admission. Postmortem lung biopsy revealed bone marrow fat embolism.
  4,361 92 1
ORIGINAL ARTICLES
Mucinous tubular and spindle cell carcinoma of kidney: A clinicopathologic study of six cases
Mudassar Hussain, Nasir Ud Din, Muhammad Azam, Asif Loya
October-December 2012, 55(4):439-442
DOI:10.4103/0377-4929.107776  PMID:23455776
Background: Mucinous tubular and spindle carcinoma (MTSCC) of kidney is a rare, low-grade polymorphic tumor. Recent studies have described a wide morphology spectrum of this tumor. Aim: To report the clinico-pathologic features of six cases of MTSCC of kidney. Materials and Methods: Six cases of MTSCC of kidney were studied and literature was reviewed. Immunohistochemistry was done by Envision method. Results: The age of the patients ranged from 44 to 84 years (mean 58.5 years). Four patients were males and two were females. The tumor was located in the left kidney in four cases and in the right kidney in two cases. The tumor size ranged from 4.5 to 15 cm (mean 6.4 cm). All tumors exhibited an admixture of tubules, spindle cells, and mucinous stroma in variable proportions. Tubules were predominant in five cases and spindle cells in one case. Psammomatous calcifications, papillations, and necrosis were seen in two cases. Collections of foamy histiocytes were noted in four cases. Cytoplasmic vacuoles and osseous metaplasia were seen in one case each. All cases were Fuhrman's nuclear grade II. Five cases were of stage pT1, and one was pT3. All cases stained positive for alcian blue at pH 2.5. Immunohistochemical stain CK7 was positive in all cases and CD10 was positive in 1/1 case. All patients were alive and well at follow-up of 12-59 months (mean 33.5 months). No metastases were detected. Conclusions: We report six cases of MTSCC of kidney, a rare distinct variant of RCC, with a favorable prognosis. A male predominance was seen in our cases. MTSCC shares histologic and immunohistochemical overlap with papillary renal cell carcinoma (PRCC) and cytogenetic analysis should be performed in difficult cases to avoid a misdiagnosis.
  3,840 194 3
CASE REPORTS
Follicular hybrid cyst on the cheek: A combination of infundibular, isthmic, and pilomatrical differentiation
Yun-Seok Choi, Sung-Kee Min, Hyung Sup Shim, Min-Cheol Kim, Jin-Soo Lim, Ki-Taik Han
October-December 2012, 55(4):563-565
DOI:10.4103/0377-4929.107823  PMID:23455808
A hybrid cyst is a rare condition which includes any type of cyst arising from the various parts of the pilosebaceous unit. We report a case of hybrid cyst with infundibular, isthmic, and pilomatrical differentiation. A 12-year-old boy presented with a mass on the right cheek. The physical examination revealed an oval-shaped, dark-gray protruding mass with dimensions of 0.9 cm × 0.6 cm that was non-tender to palpation. The mass was totally excised. The diagnosis of a hybrid cyst was confirmed by histological evaluation. It was a well-encapsulated mass and showed combined histologic features of infundibular, isthmus, and pilomatrical differentiation. The hybrid cyst is a follicular cyst that includes two or more components of a cystic lesion arising from the pilosebaceous unit. Occasionally, there have been reports of hybrid cysts consisting of two components in differentiation, but those showing more than two components of differentiation have been extremely rare. The pathogenesis of this unusual disease is not yet known.
  3,974 53 -
Testicular capillary hemangioma - A case report of a rare tumor
Shaesta N Zaidi, Amany A Fathaddin
October-December 2012, 55(4):557-559
DOI:10.4103/0377-4929.107815  PMID:23455806
Testicular hemangioma is a very rare benign vascular neoplasm, mostly occurring in children and young adults. We present a case of capillary hemangioma of the testis in a twenty three years old male who presented with painless mass in the right scrotum of 2 months duration. He was diagnosed with a right testicular tumor based on the physical examination, ultrasonography and magnetic resonance imaging studies. Serum tumor markers were normal. Right radical orchiectomy was performed. On histology, the tumor was diagnosed as capillary hemangioma of the testis. Immunohistochemical staining for CD31 and factor VIII confirmed the vascular nature of the tumor. To our knowledge, there are only twenty two cases of testicular hemangiomas reported in the literature. Although it is a rare tumor, surgeons and pathologists should be aware of it especially with the negative tumor marker findings. Intra-operative frozen section examination may be requested as tumor enucleation with testicular sparing surgery is considered adequate.
  3,884 64 4
Cytokeratin-positive primitive neuroectodermal tumor of the prostate: Case report and review of literature
Ibrahim Al Haddabi, Maiya Al Bahri, Ikram Burney
October-December 2012, 55(4):569-571
DOI:10.4103/0377-4929.107826  PMID:23455810
Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) of the prostate is extremely rare. Here, we report a case of ES/PNET of prostate in a 24-year-old man presenting with dysuria and pelvic discomfort. Computed tomography scan revealed a heterogeneous mass involving the prostate without evidence of distant metastases. Histologically, the tumor was composed of small round blue cells strongly and diffusely positive for CD99 and epithelial markers. Fluorescence in situ hybridization confirmed rearrangement of the Ewing's sarcoma region on chromosome 22.
  3,802 70 5
Mycophenolate mofetil-induced colitis with graft versus host disease-like features in a liver transplant recipient
Sushma Patra, Mukul Vij, B Sukanya, Dharmesh Kapoor
October-December 2012, 55(4):506-508
DOI:10.4103/0377-4929.107792  PMID:23455789
Mycophenolate mofetil (MMF) is a commonly used immunosuppressive drug in the management of transplant recipients. Gastrointestinal (GI) toxicity (diarrhea) is the most frequently reported adverse event in MMF-treated transplant patients. MMF-induced Graft versus Host Disease has rarely been reported in literature. We report a case of MMF-induced colitis with Graft versus Host Disease-like features, to highlight the importance of high clinical suspicion for its diagnosis, and that appropriate management in such a setting can reduce morbidity and mortality. We also review the relevant literature.
  3,553 98 4
Primary intraspinal ganglioneuroblastoma of the thoracic spine: A rare case report
Kalpalata Tripathy, Aparijita Misra, Amiya K Gouda, Srikant Das, Bidyutprava Das
October-December 2012, 55(4):535-537
DOI:10.4103/0377-4929.107805  PMID:23455798
Cerebral ganglioneuroblastoma is an embryonal tumor of the central nervous system, which has been rarely encountered into the spinal cord. The standard treatment for ganglioneuroblastoma is complete surgical excision. A 15-year old boy was presented with cord compression. Magnetic resonance imaging revealed an intradural and intramedullar enhancing lesion over T2 spine. A histomorphological diagnosis was made in the presence of immature small round cells admixed with a good number of ganglion cells. The morphological diagnosis was verified by immunohistochemistry. This is the first reported case of compressive myelopathy in the thoracic region of the spine.
  3,429 77 1
ORIGINAL ARTICLES
Molecular detection of TT virus and SEN virus infections in hemodialysed patients and blood donors in south of Iran
Rouhi Afkari, Aliyar Pirouzi, Mehdi Mohsenzadeh, Mohammad Azadi, Mohammad Jafari
October-December 2012, 55(4):478-480
DOI:10.4103/0377-4929.107784  PMID:23455783
Background: SEN virus (SEN-V) and TT virus (TTV) have been classified in the circoviridae family. Both are single-stranded, non-enveloped DNA viruses of about 3800 nucleotides. Patients on maintenance hemodialysis (HD) have a high risk of blood-borne viral infections. SEN-V and TTV has been reported from a number of HD units from various countries throughout the world. Materials and Methods: A total of 377 blood samples obtained from 150 healthy donors and 227 HD patients were collected at the HD center. SEN-V and TTV DNA was determined by polymerase chain reaction (PCR) in all samples. Results: TTV was detected in 109 (48.01%) of 227 hemodialysed patients and 14 (9.33%) of 150 voluntary blood donors (significant, P < 0.05). The PCR results for SEN-V-D/H DNA showed that 65 (28.63%) were positive for SEN-V-D and 33 (14.53%) were positive for SEN-V-H. 9.69% of 227 patients were positive for SEN-V-D/H co-infection. In the control group, SEN-V-D was detected in 14 (9.33%) and SEN-V-H was detected in 15 (10%) of the 150 (100%) blood donors. Conclusion: These findings show that the prevalence of SEN-V-D/H and TTV is higher than healthy blood donors. Also, these results indicate that the prevalence of SEN-V and TTV infections in our region is similar with that in other countries.
  3,435 63 5
Adherent Escherichia coli in colorectal mucosal biopsies: A histological and ultrastructural evaluation
Susama Patra, Subash C Samal, Gagandeep Kang, Anna Pulimood, Minnie Mathan, Balakrishnan S Ramakrishna
October-December 2012, 55(4):485-489
DOI:10.4103/0377-4929.107786  PMID:23455785
Background: Colorectal mucosal biopsies occasionally demonstrate the presence of bacteria adherent to the epithelium. This study evaluated the histological and ultrastructural correlates of such bacterial adherence. Materials and Methods: Rectal mucosal biopsies from eight patients in whom histopathological examination of biopsies had earlier demonstrated adherent bacteria were examined by electron microscopy and by bacterial culture. Colorectal biopsies of 69 patients with adherent bacteria detected histologically were retrospectively evaluated for histological changes at sites proximal and distant to adherent bacteria. Results: Escherichia coli of different serogroups were isolated from 7 of 8 rectal biopsies demonstrating bacterial adherence. All isolates showed diffuse or focal adherence to HEp-2 cell monolayers. Ultrastructural changes noted included microvillus damage, pedestal formation, actin web condensation, and protrusions of the apical cytoplasm of epithelial cells into the lumen towards the bacteria. Histological changes noted at light microscopy included reduction in epithelial cell height, focal epithelial cell degeneration, cryptitis and neutrophil infiltration at sites of bacterial adherence whereas these were usually absent at sites distant to adherent bacteria. Bacterial adherence was noted more often in biopsies from Crohn's disease patients than in patients without this diagnosis (P < 0.001). Conclusion: Adherent Escherichia coli in colorectal biopsies were associated with focal epithelial damage and showed an association with Crohn's disease.
  3,345 120 2
CASE REPORTS
Malignant pleural mesothelioma forming a huge mediastinal mass and causing atrial fibrillation
Hiroko Kuwabara, Hiroshi Tsuji, Yuki Inada, Yuro Shibayama
October-December 2012, 55(4):513-515
DOI:10.4103/0377-4929.107794  PMID:23455791
A patient with malignant pleural mesothelioma was admitted with atrial fibrillation. Chest computed tomography showed a huge mediastinal tumor adjacent to the heart. Autopsy revealed a 12 × 9.5 -cm mediastinal mass involving the right lung, which distorted and stretched the myocardial sleeve surrounding the right inferior pulmonary vein. This case demonstrates that advanced malignant pleural mesothelioma can cause atrial fibrillation, possibly by stimulating myocardium around a pulmonary vein.
  3,386 60 4
ORIGINAL ARTICLES
Application of fnbA gene as new target for the species-specific and quantitative detection of Staphylococcus aureus directly from lower respiratory tract specimens by real time PCR
Arash Ghodousi, Bizhan Nomanpour, Setareh Davoudi, Parviz Maleknejad, Maryam Omrani, Nasim Kashef, Taghi Zahraei Salehi, Mohammad Mehdi Feizabadi
October-December 2012, 55(4):490-495
DOI:10.4103/0377-4929.107787  PMID:23455786
Staphylococcus aureus is a significant cause of hospital-acquired pneumonia (HAP), particularly in mechanically ventilated patients. We used the fibronectin-binding protein A gene (fnbA) for the species-specific and quantitative detection of S. aureus directly from lower respiratory tract (LRT) specimens by a Taq Man real time PCR. For this reason, a total of 269 lower respiratory tract (LRT) specimens collected from patients with hospital-acquired pneumonia were assayed. Amplification of fnbA in serial dilutions ranged from 10 9 CFU/ ml to 10 2 CFU/ml. Standard curve of triplicate every dilution had slope 3.34 ± 0.1 and R 2 > 0.99 with SD 0.1. Based on these data, the sensitivity and specificity of the newly developed real time PCR targeting the fnbA gene were both 100%. The Cohen's Kappa test showed the Kappa value of 1.0. The fnbA gene is a potential marker for the species-specific detection of S. aureus and can be used to detect this bacterium in any clinical specimens by real time PCR. Moreover, this method reduces the time needed for quantitative detection of Staphylococcus aureus from LRT specimens to nearly 2 hours compared to 1 to 4 days for culture and provided sensitivity equal to or greater than culture.
  3,321 96 2
IMAGES
Diffuse leiomyomatosis of the uterus diagnosed during pregnancy with successful vaginal delivery
Kiran Agarwal, Neha Kawatra Madan, Meenu Pujani
October-December 2012, 55(4):585-586
DOI:10.4103/0377-4929.107836  PMID:23455816
  3,233 72 1
LETTERS TO EDITOR
Calcaneal osteosarcoma
Mahima Sharma, Vandana Sharma, Anuja Sharma, Arvind Khajuria
October-December 2012, 55(4):595-597
DOI:10.4103/0377-4929.107845  PMID:23455822
  3,185 68 2
CASE REPORTS
A unique case of well differentiated papillary mesothelioma involving an inguinal hernia
TN Anirudhan, Ranjani Chakravarthy, P Jothishankar
October-December 2012, 55(4):546-548
DOI:10.4103/0377-4929.107810  PMID:23455802
Well Differentiated Papillary Mesothelioma (WDPM) is an uncommon tumor occurring predominantly in the peritoneum of young women with no history of asbestos exposure. In this report, we present a case of 48 year old male patient presenting with indirect inguinal hernia and incidental finding of a WDPM in the hernial sac during surgery. The unusual site of presentation and the relative rarity of this neoplasm in males evoke much clinico-pathological interest.
  3,171 68 1
ORIGINAL ARTICLES
Relation of CD117 immunoreactivity and microvascular density in invasive breast carcinoma
Maha M Amin, Amira K El-Hawary, Omar Farouk
October-December 2012, 55(4):456-460
DOI:10.4103/0377-4929.107780  PMID:23455779
Background and Objective: In breast cancer, the expression of CD117 represents a highly controversial subject but the majority of studies have found decreased c-kit expression in malignant breast epithelium. A number of studies have reported that increased intratumoral microvessel density (MVD) is associated with poor prognosis in breast cancer. The aim of the study was to assess the relation of CD117 and MVD with other clinicopathological parameters in invasive breast carcinomas using the tissue microarray technique. Materials and Methods: A total of 126 cases of invasive breast carcinoma of different histological types and grades were collected from files of a pathology department during 2010. Clinicopathological and histological parameters were evaluated. Sections from formalin-fixed, paraffin-embedded tumor tissues microarray blocks were immunostained with CD117 and CD34. Statistical analysis of data was done using SPSS, version 16.0. Results: About 29% of invasive breast carcinomas were CD117 positive. There were significant differences between expression of CD117 in the tumor epithelial cells and age of the patient; tumor grade; tumor size, and LN metastasis. Also, there was significant relation between expression of CD117 in the tumor epithelial cells and MVD, expression of estrogen, and progesterone receptors. On multivariate analysis, the most important predictors of negativity of CD117 were tumor size and positive lymph node involvement. Conclusion: Lack of CD117 immunoreactivity in invasive breast carcinoma was associated with features of more aggressive tumor behavior as higher microvessel density, larger size, higher tumor grade, more lymph node metastasis, and negative estrogen and progesterone receptors.
  2,962 272 3
CASE REPORTS
Burkholderia pseudomallei infection in a healthy adult from a rural area of South India
Vaithy K Anandraj, Anbarasu Priyadharshini, Shivekar S Sunil, Raj K Ambedkar
October-December 2012, 55(4):578-579
DOI:10.4103/0377-4929.107829  PMID:23455813
Melioidosis is an emerging disease producing protean manifestations, and is more common in alcoholics and diabetics. The disease can be a trivial localized lesion or a fatal septicemia. Early diagnosis and appropriate antimicrobial treatment greatly reduces the mortality rate. We report a case of localized form of the disease in an elderly male with no known predisposing medical disease who responded well to oral amoxycillin-clavulanic acid and cotrimoxazole treatment.
  3,004 118 -
LETTERS TO EDITOR
Diaphyseal giant cell-rich osteosarcoma: Unusual histological variant in an unusual site
Prateek Kinra, Srinivas Valdamani, Vikram Singh, Vibha Dutta
October-December 2012, 55(4):600-602
DOI:10.4103/0377-4929.107848  PMID:23455825
  2,987 107 2
CASE REPORTS
Pediatric gliosarcoma with fibrosarcomatous differentiation: Report of a rare case
Shantha Ravisankar, R Vimal Chander, Prem Kumar Devadoss
October-December 2012, 55(4):521-524
DOI:10.4103/0377-4929.107797  PMID:23455794
Gliosarcoma is a rare variant of glioblastoma with a biphasic pattern showing glial and mesenchymal differentiation. It is seen in adults during their fifth to sixth decades of life and is extremely rare in children. We report a case of primary gliosarcoma with fibrosarcomatous differentiation in an 11-year-old boy presenting with headache and vomiting. Imaging showed a contrast-enhancing isodense space-occupying lesion with areas of calcification in the right temporoparietal cortex. A total excision was done and, on histopathologic examination, a differential diagnostic consideration of gliosarcoma and teratoma with malignant transformation was made. After immunohistochemical analysis, a final diagnosis of gliosarcoma with fibrosarcomatous differentiation was then made. Primary gliosarcoma is a very rare tumor in children with a poor prognosis.
  2,943 90 2
Congenital pulmonary airway malformation with mucoepidermoid carcinoma: A case report and review of literature
Narayanappa Harini, Ranjini Chakravarthy, Lakshmanan Archana
October-December 2012, 55(4):540-542
DOI:10.4103/0377-4929.107807  PMID:23455800
Congenital cystic adenomatoid malformations (CCAM) are rare developmental anomalies of the lung characterized by cysts of varying sizes and/or adenomatoid proliferation. Type I CCAM, the most frequent subtype, is associated with an increased incidence of malignant transformation, principally bronchioloalveolar carcinoma, with a reported incidence of around 1%. We report the first case of mucoepidermoid carcinoma arising in a type 1 CCAM.
  2,930 70 9
Pigmented hepatocellular adenoma with complete CD34 immunostaining pattern: A diagnostic dilemma
Mukul Vij, Sushma Patra, Mohamed Rela
October-December 2012, 55(4):528-530
DOI:10.4103/0377-4929.107801  PMID:23455796
WHO defines hepatocellular adenoma (HCA) as a benign tumor composed of cells closely resembling normal hepatocytes, which are arranged in plates separated by sinusoids. It is more common in women. The present concerns a 41 years female who was found to have a mass lesion in liver on ultrasound while undergoing routine evaluation for dyspepsia. Computed tomography scan of abdomen showed 10 × 8 cm lesion in liver. Extended left hepatectomy was performed. Grossly hepatic cut surface showed circumscribed tumor with dark gray or black color. Microscopy revealed hepatocellular adenoma with abundant Dubin Johnson like pigment deposition. CD34 immunostaining showed complete sinusoidal pattern. We labeled the tumor as pigmented hepatic adenoma with complete CD34 staining pattern. To the best of author's knowledge only eight cases of pigmented hepatocellular adenoma are described in world literature.
  2,917 73 5
ORIGINAL ARTICLES
Biochemical evaluation of the supporting structure of pelvic organs in selected numbers of premenopausal and postmenopausal Malaysian women
Sharifah Sulaiha Syed Aznal, Fong Guan Meng, Sivalingam Nalliah, Annie Tay, Kathires Chinniah, Mohd Faiz Jamli
October-December 2012, 55(4):450-455
DOI:10.4103/0377-4929.107778  PMID:23455778
Context: Pelvic organ prolapse (POP) is associated with menopause and changes in the proteins of the pelvic supporting system, but there is scant data on the precise alterations in Malaysian women. Aim: The aim of this study is to determine the differences in the extracellular matrices (ECM) of uterosacral ligaments in premenopausal and postmenopausal Malaysian women with or without POP. Settings and Design: The observational study was conducted for 9 months in three general hospitals involving 30 women who underwent hysterectomies for various indications except for carcinoma of pelvic organs. Materials and Methods: Three groups were identified: Premenopausal women (Group 1), postmenopausal women without POP (Group 2), and postmenopausal women with POP (Group 3). Age, duration of menopause, body mass index (BMI), parity, and vaginal deliveries were documented. Only 21 samples of the uterosacral ligaments were stained immunohistochemically for collagen I and III, matrix metalloproteinases (MMPs) 1 and 2, elastin, and tenascin. Statistical Analysis Used: Image J software analysis was utilized for quantification, while non-parametric statistics (Kruskal-Wallis with post-hoc Dunns Multiple Comparison test) was used for result analysis. Results: The profile parameters were not significantly different except for mean age and duration of menopause in Group 3. Samples from Group 2 showed lower expression of almost all proteins except MMP1 and tenascin (higher) as compared to Group 1. The changes appeared to be exaggerated in Group 3, though statistically insignificant. Conclusion: A significant difference in the expression of ECM was apparent in postmenopausal subjects as compared to premenopausal ( P = 0.05), compromising the uterosacral ligament tensile strength. The findings are proven similar as those changes in women from other studies.
  2,897 70 4
CASE REPORTS
Primary intravascular large B-cell lymphoma of pituitary
KR Anila, Rekha A Nair, Sumod M Koshy, Priya M Jacob
October-December 2012, 55(4):549-551
DOI:10.4103/0377-4929.107811  PMID:23455803
A 68-year-old retired nurse, who was a known hypertensive on medication, presented with prolonged fever of 2-month duration without any clinical evidence of infection. On examination she had altered mental status. She also had other nonspecific complaints such as sleep disturbances, loss of weight, etc. On investigation, she was found to have anemia, thrombocytopenia, raised erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and lactate dehydrogenase (LDH) values. She also had electrolyte imbalance. Radiological evaluation of brain showed mass lesion in the sella turcica, suggestive of pituitary adenoma. Biochemical evaluation showed hypopituitarism. Trans-sphenoidal biopsy was done. Based on histopathological and immunohistochemical findings a diagnosis of intravascular large B-cell lymphoma (IVLBCL) of pituitary was made. Our patient's condition deteriorated rapidly and she succumbed to her illness before therapy could be initiated. We are reporting this case because of the rare subtype of large B-cell lymphoma presenting at an extremely unusual primary site.
  2,864 80 3
IMAGES
Pulmonary aspergilloma with prominent oxalate deposition
Hiroko Kuwabara, Yuro Shibayama
October-December 2012, 55(4):589-590
DOI:10.4103/0377-4929.107838  PMID:23455818
  2,696 64 1
CASE REPORTS
Ectomesenchymal chondromyxoid tumor of tongue
Shan-Yin Tsai, Kung-Chao Chang, Hung-Wen Tsai, Ying-Tai Jin DDS
October-December 2012, 55(4):519-520
DOI:10.4103/0377-4929.107796  PMID:23455793
Ectomesenchymal chondromyxoid tumor (ECMT) is a rare entity of the dorsal tongue first described in 1995. Herein, we report a rare case of lingual ECMT in a 41-year-old man. Patient presented with an asymptomatic, small nodule (0.5 cm in diameter) in the anterior tongue. The pathological findings showed uni-lobular proliferation of fusiform cells, arranged in net-like sheets or swirls, in a chondromyxoid background. The tumor cells were immunoreactive for S-100 and glial fibrillary acidic protein (GFAP), but negative for epithelial markers. Familiarity with this entity helps pathologists make a correct diagnosis.
  2,574 92 4
IMAGES
Preoperative cytological diagnosis of ameloblastoma involving the maxilla
Renu Thambi, K Subitha, S Mohan, V Letha
October-December 2012, 55(4):591-592
DOI:10.4103/0377-4929.107839  PMID:23455819
  2,513 120 1
CASE REPORTS
Progression of hepatic aspergillosis following second renal transplantation in a patient with recurrent glomerulonephritis
Krishan L Gupta, KG Rajaram, Kusum Joshi, Vinay Sakhuja
October-December 2012, 55(4):580-582
DOI:10.4103/0377-4929.107831  PMID:23455814
Invasive aspergillosis is a serious complication in renal transplant recipients. Hepatic involvement, although seen in liver transplant recipients, has not been reported following renal transplantation. We describe here an interesting occurrence of hepatic Aspergillus infection in a renal transplant recipient. The infection responded to anti-fungal therapy, but there was re-activation following a second renal transplant. In addition, the patient had recurrence of the underlying membrano-proliferative glomerulonephritis following both transplants. The relevant existing literature relating to these problems has been reviewed.
  2,569 55 -
LETTERS TO EDITOR
Evaluation of immunochromatographic test in early serological diagnosis of dengue fever
D Kalyani, M Meera Bai
October-December 2012, 55(4):610-611
DOI:10.4103/0377-4929.107863  PMID:23455833
  2,472 135 -
CASE REPORTS
Ovarian hemangioma with stromal luteinization and HCG-producing mononucleate and multinucleate cells of uncertain histogenesis: A rare co-existence with therapeutic dilemma
Murthy S Anand, Shakila Shetty, Vijaya V Mysorekar, Rekha V Kumar
October-December 2012, 55(4):509-512
DOI:10.4103/0377-4929.107793  PMID:23455790
A 21 year old female presented with amenorrhea, hirsutism and change in voice along with an elevated serum β-HCG (human chorionic gonadotrophin) level and normal CA-125 level. Laparotomy revealed an enlarged right ovary measuring 6 × 5 × 1 cms with presence of an ovarian hemangioma along with stromal luteinization and HCG producing mononucleate as well as multinucleate cells of uncertain histogenesis on histopathological examination. Immunohistochemistry for inhibin and calretinin were positive in the luteinized component whereas β-HCG and Ki-67 were positive in the multinucleate cell component. The diagnostic rarity and therapeutic dilemma of such a rare mixed tumor within a single ovary has proven to be an exceptional case and an excellent investigative opportunity.
  2,470 74 2
Fibro-osteochondroma of the uterus
Alan W. H. Bates, Manisha Ram
October-December 2012, 55(4):555-556
DOI:10.4103/0377-4929.107814  PMID:23455805
A case of a uterine fibro-osteochondroma in a 61-year-old woman with postmenopausal bleeding was presented. Ultrasound revealed a calcified lesion in the posterior wall of the uterus and a hysterectomy was performed. Histopathologic examination showed a well-circumscribed triphasic tumor composed of peripheral lobules of mature hyaline cartilage and foci of trabecular bone with a core of loosely arranged fibroblast-like, spindle cells. This is the second reported case of fibro-osteochondroma, which has been described only in the uterus. Diagnosis requires thorough histopathologic examination to exclude metaplasia within a leiomyoma or uterine sarcoma. It is histologically benign and complete excision should be curative.
  2,443 70 -
LETTERS TO EDITOR
Cytomegalovirus pneumonia in a neonate presenting as a space occupying lesion mimicking a tumor
Bhanumati K Rao, Marjorie M. A. Correa, Sanjay Rao
October-December 2012, 55(4):611-613
DOI:10.4103/0377-4929.107866  PMID:23455834
  2,363 64 -
CASE REPORTS
Cervical metastasis of esophagogastric junction cancer
Zhiqiang Cai, Xiaoyan Shu, Junchuan Li, Jiyuan Yang
October-December 2012, 55(4):560-562
DOI:10.4103/0377-4929.107820  PMID:23455807
As cervical metastases in esophagogastric junction cancer are extremely rare, the authors herein report a case. A 63-year-old woman presented with dysphagia since 6 months. Diagnostic endoscopy showed that the tumor was located at the esophagogastric junction and histopathological diagnosis of adenocarcinoma was offered. A subtotal gastrectomy was performed. Histopathological diagnosis was moderately differentiated adenocarcinoma, invading upto the serosa with metastases to perigastric nodes. The patient received chemotherapy of cisplatin and fluorouracil for one cycle and oral capecitabine for two cycles. Two years later, the patient presented with vaginal bleeding and magnetic resonance imaging of pelvis revealed a tumor of the cervix. Histopathological impression of the tumor was metastatic cervical adenocarcinoma and immunohistochemistry showed the tumor was cytokeratin, villin, and CDX2 were positive and cytokeratin 20, CA125, and CA199 were negative. The immunohistochemical profile was the same as that of primary.
  2,265 54 1
Postchemotherapy-related changes in mediastinal mixed germ cell tumor masquerading as a vascular neoplasm
Monalisa Hui, Ashwani Tandon, Shantveer G Uppin, RK Paruchuri
October-December 2012, 55(4):531-534
DOI:10.4103/0377-4929.107803  PMID:23455797
Florid vascular proliferation in teratoma is rare morphological presentation. We present a case of mediastinal germ cell tumor masquerading as a vascular neoplasm in a 14-year-old male who presented with right hemithoracic mass. The initial histopathology of resected mass was suggestive of vascular neoplasm. Fine needle aspiration cytology (FNAC) of right axillary mass with immunohistochemistry on cell block was consistent with metastatic mixed germ cell tumor. Repeat extensive sectioning of the resected mediastinal mass showed focal viable tumor with mainly teratomatous component. Further enquiry into the history revealed patient having received prior chemotherapy; this he received in another hospital before being admitted to our hospital for surgical resection of the mass. The florid vascular proliferation may represent postchemotherapy change or a rare component of germ cell tumor possibly resistant to preoperative chemotherapy.
  2,098 68 2
A case of collision tumor or transdifferentiation between malignant melanoma and leiomyosarcoma
Jamshaid Ul-Mulk, Helle Rasmussen, Line Breiting, Elsebeth Siim
October-December 2012, 55(4):538-539
DOI:10.4103/0377-4929.107806  PMID:23455799
A 73-year-old woman was referred to the hospital due to a pigmented, asymptomatic nevus on her right arm that had changed in size and color. The histopathological examination showed a superficial spreading malignant melanoma, Clark level III, 2.26 mm in thickness. Two years later, the patient presented a 10 cm rapidly growing mass in her right axilla. The mass in the axilla measured 12.5 ΄ 9 ΄ cm. It revealed a lymph node metastases with a tumor growth composed of two different contiguous morphological and immunohistochemical components, respectively, melanosomes and leiomyosarcoma. The combination of a melanocytic nevus with other tumor of epidermal or adnexal origin has been described before, but still the co-existence of two different neoplasms within a lesion is still uncommon. The most common combination is basal cell carcinoma and melanocytic nevus or one of them together with a seborrheic keratosis. There have also been occasional reports of rhabdomyosarcomatous differentiation. However, mesenchymal differentiation, and in this case leiomysarcoma, with formation of heterologous elements in melanocytic tumor is very rare. Another plausible explanation may be that malignant melanoma cells could have transdifferentiated into a leiomyosarcomatoid phenotype with resulting metastases of either type. Malignant melanomas have shown a wide variety of cytological changes and can mimic carcinomas, lymphomas, and sarcomas. Spindle cell melanomas commonly simulate spindle cell carcinomas. It has also been documented that desmoplastic melanomas can change into fibroblastic, Schwannian, and myofibroblastic differentiation.
  2,071 59 3
Renal cell carcinoma metastasizing to adenocarcinoma of esophagogastric junction: A rare case of tumor-to-tumor metastasis
Renu Sukumaran, Anitha Mathews, Thara Somanathan, Jayasree Kattoor
October-December 2012, 55(4):525-527
DOI:10.4103/0377-4929.107799  PMID:23455795
The simultaneous occurrence of two primary tumors in one patient is not uncommon, but one tumor metastasizing to another malignancy is a rare phenomenon. Tumor-to-tumor metastasis was first described by Berent in 1902. Since then fewer than 200 cases have been reported in the literature. In most of these cases renal cell carcinoma acted as a recipient tumor. In tumor-to-tumor metastasis renal cell carcinoma acting as a donor is exceedingly rare and there are no reported cases of adenocarcinoma of the esophagogastric junction acting as a recipient. We present a case of renal cell carcinoma metastasizing to an adenocarcinoma of esophagogastric junction. To our knowledge, this is the first reported case of such a combination.
  1,994 101 -
LETTERS TO EDITOR
Salmonella enterica serovar Typhi in breast abscess: A case report
E Sathish Kumar, R Esther Mary Selvam, S Srivani Ramesh
October-December 2012, 55(4):608-609
DOI:10.4103/0377-4929.107857  PMID:23455830
  1,953 89 3
IMAGES
A case of primitive neuroectodermal tumor of the kidney and review of the literature
Sanish S Shringarpure, Murali Venkatraman, T Raja, Rama Mani
October-December 2012, 55(4):587-588
DOI:10.4103/0377-4929.107837  PMID:23455817
  1,883 74 -
LETTERS TO EDITOR
Perineurial soft tissue tumors: A tale of three cases exemplifying underdiagnoses of these "uncommon" tumors
Bharat Rekhi
October-December 2012, 55(4):598-600
DOI:10.4103/0377-4929.107847  PMID:23455824
  1,858 62 -
Juvenile Hyaline Fibromatosis or Hyaline Fibromatosis Syndrome?
Bhavana Bharambe
October-December 2012, 55(4):610-610
DOI:10.4103/0377-4929.107860  PMID:23455832
  1,852 47 1
High-risk HPV-16 DNA testing after treatment for carcinoma cervix
Veena Kashyap, Suresh Hedau
October-December 2012, 55(4):594-595
DOI:10.4103/0377-4929.107842  PMID:23455821
  1,793 62 -
Psoas and thyroid abscess in a renal allograft recipient
R Deepa, S Thasneem Banu, G Jayalakshmi, J Durdana Parveen
October-December 2012, 55(4):593-594
DOI:10.4103/0377-4929.107840  PMID:23455820
  1,736 52 1
Multidrug-resistant Shigella flexneri bacteremia in an immunocompetent adult
Frenil C Munim, Kalwaje E Vandana, Vasudeva Acharya, Chiranjay Mukhopadhyay
October-December 2012, 55(4):607-608
DOI:10.4103/0377-4929.107855  PMID:23455829
  1,638 67 -
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