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  Indian J Med Microbiol
 

Figure 2: Key stains in the diagnosis of hepatocellular carcinoma. (a). Reticulin showing thickening of hepatic cell plates and focal loss of reticulin fibers. (b) CD34-diffuse capillarization of sinusoids in the tumor (left) (inset – intense cytoplasmic staining of sinusoidal endothelial cells). (c) Hep Par1-intense granular cytoplasmic staining in moderately differentiated hepatocellular carcinoma (inset – high power). (d) Glypican 3 diffuse cytoplasmic positivity in a well-differentiated hepatocellular carcinoma (inset – high power). (e) heat shock protein 70-strong cytoplasmic and nuclear positivity in moderately differentiated hepatocellular carcinoma (inset– high power). (f) Polyclonal CEA-canalicular positivity in the part of the tumor (left) and membranous positivity (right) (inset – canalicular staining)

Figure 2: Key stains in the diagnosis of hepatocellular carcinoma. (a). Reticulin showing thickening of hepatic cell plates and focal loss of reticulin fibers. (b) CD34-diffuse capillarization of sinusoids in the tumor (left) (inset – intense cytoplasmic staining of sinusoidal endothelial cells). (c) Hep Par1-intense granular cytoplasmic staining in moderately differentiated hepatocellular carcinoma (inset – high power). (d) Glypican 3 diffuse cytoplasmic positivity in a well-differentiated hepatocellular carcinoma (inset – high power). (e) heat shock protein 70-strong cytoplasmic and nuclear positivity in moderately differentiated hepatocellular carcinoma (inset– high power). (f) Polyclonal CEA-canalicular positivity in the part of the tumor (left) and membranous positivity (right) (inset – canalicular staining)