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  Indian J Med Microbiol
 

Figure 4: Subtyping of hepatocellular adenoma. (a) Loss of liver fatty acid binding protein in hepatocyte nuclear factor 1α-mutated hepatic adenoma (b) Strong granular cytoplasmic expression of C-reactive protein in inflammatory hepatic adenoma. Serum amyloid A expression is similar. (c) Strong aberrant nuclear staining of β-catenin in β-catenin-mutated hepatic adenoma. (d) β-catenin-mutated hepatic adenomas show diffuse positivity for glutamine synthetase (GS), a surrogate marker for Wnt signaling activation. (e) Example of hepatic adenoma that is negative for glutamine synthetase with patchy peripheral staining, while the adjacent liver shows normal perivenular staining pattern (f) Focal nodular hyperplasia showing geographic (map like) staining pattern for glutamine synthetase

Figure 4: Subtyping of hepatocellular adenoma. (a) Loss of liver fatty acid binding protein in hepatocyte nuclear factor 1<b>α</b>-mutated hepatic adenoma (b) Strong granular cytoplasmic expression of C-reactive protein in inflammatory hepatic adenoma. Serum amyloid A expression is similar. (c) Strong aberrant nuclear staining of <b>β</b>-catenin in <b>β</b>-catenin-mutated hepatic adenoma. (d) <b>β</b>-catenin-mutated hepatic adenomas show diffuse positivity for glutamine synthetase (GS), a surrogate marker for Wnt signaling activation. (e) Example of hepatic adenoma that is negative for glutamine synthetase with patchy peripheral staining, while the adjacent liver shows normal perivenular staining pattern (f) Focal nodular hyperplasia showing geographic (map like) staining pattern for glutamine synthetase